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Tbio
PLP2
Proteolipid protein 2

Protein Summary
Description
May play a role in cell differentiation in the intestinal epithelium. This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376322
  • ENSP00000365500
  • ENSG00000102007
  • ENST00000376327
  • ENSP00000365505

Symbol
  • A4
  • A4
  • A4LSB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
hub protein
0.88
gene perturbation
0.83
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.39   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.39   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (25)
1 – 10 of 25
LACC1
Tbio
Family: Enzyme
Novelty: 0.03928871
p_int: 0.838466389
p_ni: 0.000029179
p_wrong: 0.161504432
Score: 0.195
Data Source: BioPlex,STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.947
Data Source: STRINGDB
PDCL2
Tbio
Novelty: 0.10154162
Score: 0.906
Data Source: STRINGDB
SLC12A4
Tbio
Family: Transporter
Novelty: 0.01077688
Score: 0.82
Data Source: STRINGDB
PDCL3
Tbio
Novelty: 0.05786581
Score: 0.808
Data Source: STRINGDB
PTCD3
Tbio
Novelty: 0.12368434
Score: 0.787
Data Source: STRINGDB
TUBB
Tclin
Novelty: 0.0038007
Score: 0.64
Data Source: STRINGDB
TUBB2A
Tclin
Novelty: 0.00902924
Score: 0.64
Data Source: STRINGDB
TCP1
Tbio
Novelty: 0.00395241
Score: 0.621
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.618
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.39

PubMed score by year
PubTator Score  25.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer