Tbio PLP2 Proteolipid protein 2

Protein Summary

Description

May play a role in cell differentiation in the intestinal epithelium. This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q04941
• A6NDT7
• Q32MM8

Gene Name

• PLP2

Ensembl ID

• ENST00000376322
• ENSP00000365500
• ENSG00000102007
• ENST00000376327
• ENSP00000365505

Symbol

• A4
• A4
• A4LSB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.98
hub protein	0.88
gene perturbation	0.83
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.49   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.49   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0