Protein Summary
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
- ENST00000248975
- ENSP00000248975
- ENSG00000128245
- YWHA1
- YWHA1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
biological process | 0.95 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.65 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 283 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.65 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 283 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (223)
FAM86C1
Family: Enzyme
Novelty: 1.61781609
p_int: 0.99838002
p_ni: 0.00161998
Data Source: BioPlex
SMTNL2
Novelty: 0.33805653
p_int: 0.997100407
p_ni: 0.002899593
Score: 0.257
Data Source: BioPlex,STRINGDB
KIAA0930
Novelty: 0.16492958
p_int: 0.965409562
p_ni: 0.034590438
Score: 0.219
Data Source: BioPlex,STRINGDB
BRAF
Family: Kinase
Novelty: 0.00253795
p_int: 0.961179982
p_ni: 0.038820018
Score: 0.956
Data Source: BioPlex,STRINGDB
CGN
Novelty: 0.01097394
p_int: 0.956677909
p_ni: 0.043322091
Score: 0.588
Data Source: BioPlex,STRINGDB
SPATA13
Novelty: 0.19610601
p_int: 0.93420564
p_ni: 0.06579436
Score: 0.374
Data Source: BioPlex,STRINGDB
SAMD4A
Novelty: 0.04440962
p_int: 0.925524414
p_ni: 0.074475586
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (61)
Reactome (22)
KEGG (6)
PathwayCommons (29)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of BAD and translocation to mitochondria | ||||
Reactome | Activation of BH3-only proteins | ||||
Reactome | Apoptosis | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of BAD and translocation to mitochondria | ||||
Activation of BH3-only proteins | ||||
Apoptosis | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (9)
Components (8)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.8 | 59 | |||||
HbA1c measurement | 1 | 1 | 1 | 58.4 | |||||
1,5 anhydroglucitol measurement | 1 | 1 | 0 | 7.2 | 56.6 | ||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 55.2 | |||||
mathematical ability | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.8 | 59 | |||||
HbA1c measurement | 1 | 58.4 | |||||
1,5 anhydroglucitol measurement | 0 | 7.2 | 56.6 | ||||
monocyte percentage of leukocytes | 1 | 55.2 | |||||
mathematical ability | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | VGNC:10128 | 458778 | |||||
Macaque | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | 717016 | ||||||
Mouse | MGI:109194 | 22629 | ||||||
Rat | RGD:3978 | 25576 | ||||||
Dog | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | VGNC:52975 | 100687866 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | |||||
Macaque | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | |||||
Mouse | ||||||
Rat | ||||||
Dog | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta | |||||
Publication Statistics
PubMed Score 109.65
PubMed score by year
PubTator Score 31.62
PubTator score by year
Related Publications
Text Mined References (114)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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