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Tchem
YWHAH
14-3-3 protein eta

Protein Classes
Protein Summary
Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248975
  • ENSP00000248975
  • ENSG00000128245

Symbol
  • YWHA1
  • YWHA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
biological process
0.95
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.01   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.01   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3814675
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
1
1.1
44.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
44.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (61)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (30)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (223)
1 – 10 of 223
FAM86C1
Tdark
Family: Enzyme
Novelty: 1.61781609
p_int: 0.99838002
p_ni: 0.00161998
Data Source: BioPlex
SMTNL2
Tdark
Novelty: 0.33805653
p_int: 0.997100407
p_ni: 0.002899593
Score: 0.257
Data Source: BioPlex,STRINGDB
LNP1
Tdark
Novelty: 0.00457285
p_int: 0.981245747
p_ni: 0.018754253
Data Source: BioPlex
KIAA0930
Tbio
Novelty: 0.16492958
p_int: 0.965409562
p_ni: 0.034590438
Score: 0.219
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.961179982
p_ni: 0.038820018
Score: 0.956
Data Source: BioPlex,STRINGDB
CGN
Tbio
Novelty: 0.01097394
p_int: 0.956677909
p_ni: 0.043322091
Score: 0.588
Data Source: BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty: 0.26347141
p_int: 0.956505194
p_ni: 0.043494806
Data Source: BioPlex
SPATA13
Tbio
Novelty: 0.19610601
p_int: 0.93420564
p_ni: 0.06579436
Score: 0.374
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.930919254
p_ni: 0.069080746
Data Source: BioPlex
SAMD4A
Tbio
Novelty: 0.04440962
p_int: 0.925524414
p_ni: 0.074475586
Score: 0.169
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  106.01

PubMed score by year
PubTator Score  31.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer