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Tchem
MST1R
Macrophage-stimulating protein receptor

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in respon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296474
  • ENSP00000296474
  • ENSG00000164078
  • ENST00000344206
  • ENSP00000341325
  • ENST00000621387
  • ENSP00000482642

Symbol
  • PTK8
  • RON
  • RON
  • PTK8
  • CD136
  • NPCA3
  • CDw136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
hub protein
0.96
biological process
0.75
PubMedID
0.7


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.58   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 831   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.58   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 831   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
crizotinib
Rendered image for crizotinib
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
14
7
7
95.9
household income
2
5
5
94.8
self reported educational attainment
7
6
6
1.1
94.3
body mass index
6
3
6
93.1
C-reactive protein measurement
3
3
3
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
7
95.9
household income
5
94.8
self reported educational attainment
6
1.1
94.3
body mass index
6
93.1
C-reactive protein measurement
3
89.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
macrophage stimulating 1 receptor
VGNC:2431
744480
Macaque
macrophage stimulating 1 receptor
704437
Mouse
MGI:99614
19882
Rat
RGD:1306465
300999
Dog
macrophage stimulating 1 receptor
VGNC:43452
444854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
macrophage stimulating 1 receptor
Macaque
macrophage stimulating 1 receptor
Mouse
Rat
Dog
macrophage stimulating 1 receptor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (99)
1 – 10 of 99
MST1
Tchem
Family:  Enzyme
Novelty:  0.00781564
Score:  0.998
Data Source:  Reactome,STRINGDB
SFN
Tbio
Novelty:  0.00340233
Score:  0.96
Data Source:  STRINGDB
YWHAH
Tchem
Novelty:  0.01000071
Score:  0.948
Data Source:  STRINGDB
YWHAQ
Tchem
Novelty:  0.00234496
Score:  0.947
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.947
Data Source:  STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.947
Data Source:  STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
Score:  0.947
Data Source:  STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
Score:  0.947
Data Source:  STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
Score:  0.947
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  499.58

PubMed score by year
PubTator Score  384.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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