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Tbio
CD164
Sialomucin core protein 24

Protein Summary
Description
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275080
  • ENSP00000275080
  • ENSG00000135535
  • ENST00000310786
  • ENSP00000309376
  • ENST00000324953
  • ENSP00000314177
  • ENST00000413644
  • ENSP00000402237
  • ENST00000512821
  • ENSP00000427546

Symbol
  • DFNA66
  • MGC-24
  • MUC-24
  • MGC-24v
  • endolyn
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
virus perturbation
0.98
transcription factor perturbation
0.91
kinase perturbation
0.84
microRNA
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.56   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.56   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
4
4
98.9
erythrocyte count
4
4
4
97.6
red blood cell density measurement
2
2
2
95.9
red blood cell distribution width
4
2
4
95.8
basophil count
4
4
4
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
98.9
erythrocyte count
4
97.6
red blood cell density measurement
2
95.9
red blood cell distribution width
4
95.8
basophil count
4
92.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD164 molecule
VGNC:7166
462926
Macaque
CD164 molecule
699242
Mouse
MGI:1859568
53599
Rat
RGD:70942
83689
Dog
CD164 molecule
VGNC:38932
475020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD164 molecule
Macaque
CD164 molecule
Mouse
Rat
Dog
CD164 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04900-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (38)
1 – 10 of 38
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.784
Data Source:  STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
Score:  0.769
Data Source:  STRINGDB
TXNL1
Tbio
Novelty:  0.01151931
Score:  0.713
Data Source:  STRINGDB
ACKR3
Tchem
Family:  GPCR
Novelty:  0.00727792
Score:  0.709
Data Source:  STRINGDB
ITGA3
Tchem
Novelty:  0.00505981
Score:  0.682
Data Source:  STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
Score:  0.68
Data Source:  STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
Score:  0.675
Data Source:  STRINGDB
WASHC4
Tdark
Novelty:  0.05930527
Score:  0.674
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.617
Data Source:  STRINGDB
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
Score:  0.608
Data Source:  STRINGDB
Publication Statistics
PubMed Score  47.56

PubMed score by year
PubTator Score  25.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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