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Tbio
REL
Proto-oncogene c-Rel

Protein Summary
Description
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an ina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295025
  • ENSP00000295025
  • ENSG00000162924
  • ENST00000394479
  • ENSP00000377989

Symbol
  • C-Rel
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
virus perturbation
0.92
PubMedID
0.9
biological process
0.86
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2314.15   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 769   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2314.15   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 769   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
1
1.1
91.4
3
2
0
1.2
87.5
4
3
0
1.2
84.6
2
2
0
1.1
83.4
5
3
3
1.1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
91.4
0
1.2
87.5
0
1.2
84.6
0
1.1
83.4
3
1.1
82
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
REL proto-oncogene, NF-kB subunit
VGNC:10284
470380
Macaque
REL proto-oncogene, NF-kB subunit
717804
Mouse
MGI:97897
19696
Rat
RGD:1311231
305584
Dog
REL proto-oncogene, NF-kB subunit
VGNC:45465
474606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
REL proto-oncogene, NF-kB subunit
Macaque
REL proto-oncogene, NF-kB subunit
Mouse
Rat
Dog
REL proto-oncogene, NF-kB subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04864-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Downstream signaling events of B Cell Receptor (BCR)
Immune System
Signaling by the B Cell Receptor (BCR)
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (281)
1 – 10 of 281
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
RELB
Tbio
Family:  TF
Novelty:  0.00216805
p_int:  1
Score:  0.947
Data Source:  BioPlex,STRINGDB
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
p_int:  0.999999979
p_ni:  2.1e-8
Score:  0.971
Data Source:  BioPlex,STRINGDB
NFKBIE
Tbio
Novelty:  0.01726154
p_int:  0.999999819
p_ni:  1.59e-7
p_wrong:  2.2e-8
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
p_int:  0.999999755
p_ni:  2.45e-7
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
p_int:  0.999999322
p_ni:  6.77e-7
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999961869
p_ni:  0.000038131
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999952159
p_ni:  0.000047841
Score:  0.338
Data Source:  BioPlex,STRINGDB
NFKBID
Tbio
Novelty:  0.04272718
p_int:  0.999753772
p_ni:  0.000246228
Score:  0.931
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2314.15

PubMed score by year
PubTator Score  605.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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