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Tclin
CHRNE
Acetylcholine receptor subunit epsilon

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293780
  • ENSP00000293780
  • ENSG00000108556
  • ENST00000649488
  • ENSP00000497829

Symbol
  • ACHRE
  • ACHRE
  • CMS1D
  • CMS1E
  • CMS2A
  • CMS4A
  • CMS4B
  • CMS4C
  • FCCMS
  • SCCMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.84
disease perturbation
0.74
gene perturbation
0.74
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
7
8
4.2
98.7
mean platelet volume
3
5
7
96.6
platelet crit
2
3
3
92.4
blood metabolite measurement
2
2
2
89
sphingomyelin measurement
1
2
3
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
4.2
98.7
mean platelet volume
7
96.6
platelet crit
3
92.4
blood metabolite measurement
2
89
sphingomyelin measurement
3
84.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic epsilon subunit
VGNC:12052
468165
Macaque
cholinergic receptor nicotinic epsilon subunit
710301
Mouse
MGI:87894
11448
Rat
RGD:2353
29422
Dog
cholinergic receptor nicotinic epsilon subunit
VGNC:39247
479471
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic epsilon subunit
Macaque
cholinergic receptor nicotinic epsilon subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic epsilon subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04844-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Postsynaptic nicotinic acetylcholine receptors
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly sodium permeable acetylcholine nicotinic receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Postsynaptic nicotinic acetylcholine receptors
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (59)
1 – 10 of 59
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
Score:  0.977
Data Source:  STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.91
Data Source:  Reactome,STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.91
Data Source:  Reactome,STRINGDB
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.91
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.909
Data Source:  STRINGDB
CHRNG
Tclin
Family:  IC
Novelty:  0.03295438
Score:  0.904
Data Source:  STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
Score:  0.899
Data Source:  STRINGDB
MINK1
Tchem
Family:  Kinase
Novelty:  0.00505208
Score:  0.815
Data Source:  STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
Score:  0.796
Data Source:  STRINGDB
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.795
Data Source:  STRINGDB
Publication Statistics
PubMed Score  54.67

PubMed score by year
PubTator Score  54.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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