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Tbio
SSBP1
Single-stranded DNA-binding protein, mitochondrial

Protein Summary
Description
This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA. SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265304
  • ENSP00000265304
  • ENSG00000106028
  • ENST00000465582
  • ENSP00000420485
  • ENST00000481508
  • ENSP00000419665
  • ENST00000484178
  • ENSP00000419388
  • ENST00000498107
  • ENSP00000419541
  • ENST00000570667
  • ENSP00000460028
  • ENSG00000262771
  • ENST00000571430
  • ENSP00000459367
  • ENST00000574199
  • ENSP00000461884
  • ENST00000575059
  • ENSP00000458815
  • ENST00000576834
  • ENSP00000459208
  • ENST00000612337
  • ENSP00000480488

Symbol
  • SSBP
  • SSBP
  • mtSSB
  • Mt-SSB
  • SOSS-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor binding site profile
0.95
histone modification site profile
0.9
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.4   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.4   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Mitochondrial biogenesis (R-HSA-1592230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (183)
1 – 10 of 183
GOLPH3
Tbio
Novelty: 0.00023848
p_int: 0.999755028
p_ni: 0.000244922
p_wrong: 5.1e-8
Data Source: BioPlex
CST8
Tbio
Novelty: 0.00274495
p_int: 0.999362919
p_ni: 0.000103605
p_wrong: 0.000533476
Data Source: BioPlex
HERC2
Tbio
Family: Enzyme
Novelty: 0.05519779
p_int: 0.990712375
p_ni: 0.009287625
Data Source: BioPlex
NUDT12
Tbio
Family: Enzyme
Novelty: 0.40327445
p_int: 0.898169081
p_ni: 0.031001888
p_wrong: 0.070829032
Data Source: BioPlex
MAP7
Tbio
Novelty: 0.02738196
p_int: 0.783644928
p_ni: 0.216355072
Data Source: BioPlex
TWNK
Tbio
Novelty: 0.00568711
Score: 0.917
Data Source: STRINGDB
GABPA
Tbio
Family: TF
Novelty: 0.02865138
Score: 0.913
Data Source: STRINGDB
INIP
Tbio
Novelty: 0.01535967
Score: 0.905
Data Source: STRINGDB
SSBP2
Tbio
Novelty: 0.07797045
Score: 0.901
Data Source: STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00215894
Score: 0.888
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.40

PubMed score by year
PubTator Score  68.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer