AKR1C1
Aldo-keto reductase family 1 member C1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
small molecule perturbation | 0.95 | ||
chemical | 0.91 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.83 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of fat-soluble vitamins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Metabolism | ||||
Metabolism of fat-soluble vitamins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 3 | 4 | 95.6 | |||||
waist-hip ratio | 3 | 8 | 9 | 90.1 | |||||
BMI-adjusted waist-hip ratio | 3 | 6 | 7 | 86.1 | |||||
hip circumference | 1 | 5 | 5 | 73 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 63.6 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 95.6 | |||||
waist-hip ratio | 9 | 90.1 | |||||
BMI-adjusted waist-hip ratio | 7 | 86.1 | |||||
hip circumference | 5 | 73 | |||||
BMI-adjusted waist circumference | 2 | 63.6 | |||||
PMID | Year | Title |
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