Tchem AKR1C1 Aldo-keto reductase family 1 member C1

Protein Summary

Description

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q04828
• P52896
• Q5SR15
• Q7M4N2
• Q9UCX2

Gene Name

• AKR1C1

Ensembl ID

• ENST00000380872
• ENSP00000370254
• ENSG00000187134

Symbol

• DDH
• DDH1
• C9
• DD1
• DDH
• DDH1
• H-37
• HBAB
• MBAB
• HAKRC
• DD1/DD2
• 2-ALPHA-HSD
• 20-ALPHA-HSD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule perturbation	0.95
chemical	0.91
transcription factor perturbation	0.84
PubMedID	0.83

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C1

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.3   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.3   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5