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Tchem
AKR1C1
Aldo-keto reductase family 1 member C1

Protein Summary
Description
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380872
  • ENSP00000370254
  • ENSG00000187134

Symbol
  • DDH
  • DDH1
  • C9
  • DD1
  • DDH
  • DDH1
  • H-37
  • HBAB
  • MBAB
  • HAKRC
  • DD1/DD2
  • 2-ALPHA-HSD
  • 20-ALPHA-HSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule perturbation
0.95
chemical
0.91
transcription factor perturbation
0.84
PubMedID
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.96   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.96   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Gene Ontology Terms (33)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (71)
1 – 10 of 71
AKR1C3
Tchem
Family: Enzyme
Novelty: 0.00257785
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
AKR1C2
Tchem
Family: Enzyme
Novelty: 0.00134228
p_int: 1
Score: 0.991
Data Source: BioPlex,STRINGDB
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999899971
p_ni: 0.000067347
p_wrong: 0.000032682
Score: 0.986
Data Source: BioPlex,STRINGDB
DHDH
Tbio
Family: Enzyme
Novelty: 0.00284827
Score: 0.984
Data Source: STRINGDB
SRD5A1
Tclin
Family: Enzyme
Novelty: 0.00987219
Score: 0.965
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.952
Data Source: STRINGDB
SRD5A2
Tclin
Family: Enzyme
Novelty: 0.00281044
Score: 0.952
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.95
Data Source: STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.939
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  237.96

PubMed score by year
PubTator Score  278.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer