Tchem AKR1C1 Aldo-keto reductase family 1 member C1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C1

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C1

Protein Summary

Description

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q04828
• P52896
• Q5SR15
• Q7M4N2
• Q9UCX2

Gene Name

• AKR1C1

Ensembl ID

• ENST00000380872
• ENSP00000370254
• ENSG00000187134

Symbol

• DDH
• DDH1
• C9
• DD1
• DDH
• DDH1
• H-37
• HBAB
• MBAB
• HAKRC
• DD1/DD2
• 2-ALPHA-HSD
• 20-ALPHA-HSD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
small molecule perturbation	0.95
chemical	0.91
transcription factor perturbation	0.84
PubMedID	0.83

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.96   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.96   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

flufenamic acid

AKR1C1Tchem Enzyme

IC50 : 6.01

medroxyprogesterone

AKR1C1Tchem Enzyme

IC50 : 6.16

mefenamic acid

AKR1C1Tchem Enzyme

Ki : 6.09

benzbromarone

AKR1C1Tchem Enzyme

IC50 : 7.32

Active Ligands (23)

Explore Active Ligands

1 – 10 of 23

CHEMBL2323511

AKR1C1Tchem Enzyme

IC50 : 7

CHEMBL2323522

AKR1C1Tchem Enzyme

IC50 : 7.12

CHEMBL2323507

AKR1C1Tchem Enzyme

IC50 : 7.75

CHEMBL2323472

AKR1C1Tchem Enzyme

IC50 : 7

CHEMBL2323508

AKR1C1Tchem Enzyme

IC50 : 7.51

CHEMBL2172108

AKR1C1Tchem Enzyme

IC50 : 6.08

CHEMBL2172091

AKR1C1Tchem Enzyme

IC50 : 6.13

CHEMBL387536

AKR1C1Tchem Enzyme

Ki : 8.4

CHEMBL1275725

AKR1C1Tchem Enzyme

Ki : 8.89

CHEMBL1275703

AKR1C1Tchem Enzyme

Ki : 9.07

Protein Structure (5 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (21)

Reactome (16)

KEGG (2)

WikiPathways (3)

Bile acid and bile salt metabolism (R-HSA-194068)

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Find Similar Targets

Items per page:

5

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of fat-soluble vitamins	48 targets	R-HSA-6806667

Name	Explore in Pharos	Explore in Source
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
Metabolism	2112 targets	R-HSA-1430728
Metabolism of fat-soluble vitamins	48 targets	R-HSA-6806667

Gene Ontology Terms (33)

Functions (14)

Components (2)

Processes (17)

Find Similar Targets

Items per page:

10

1 – 10 of 14

GO Term	Evidence	Assigned by
alditol:NADP+ 1-oxidoreductase activity	Inferred from Direct Assay (IDA)	UniProtKB
androsterone dehydrogenase (B-specific) activity	Inferred from Direct Assay (IDA)	UniProtKB
bile acid binding	Inferred from Direct Assay (IDA)	UniProtKB
carboxylic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
ketosteroid monooxygenase activity	Inferred from Direct Assay (IDA)	UniProtKB
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Inferred from Direct Assay (IDA)	UniProtKB
phenanthrene 9,10-monooxygenase activity	Inferred from Direct Assay (IDA)	UniProtKB
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	Inferred from Direct Assay (IDA)	UniProtKB
alcohol dehydrogenase (NADP+) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxidoreductase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

AKR1C3

Tchem

Family: Enzyme

Novelty: 0.00257785

p_int: 1

Score: 0.995

Data Source: BioPlex,STRINGDB

AKR1C2

Tchem

Family: Enzyme

Novelty: 0.00134228

p_int: 1

Score: 0.991

Data Source: BioPlex,STRINGDB

AKR1D1

Tbio

Family: Enzyme

Novelty: 0.01264297

p_int: 0.999899971

p_ni: 0.000067347

p_wrong: 0.000032682

Score: 0.986

Data Source: BioPlex,STRINGDB

DHDH

Tbio

Family: Enzyme

Novelty: 0.00284827

Score: 0.984

Data Source: STRINGDB

SRD5A1

Tclin

Family: Enzyme

Novelty: 0.00987219

Score: 0.965

Data Source: STRINGDB

HSD3B1

Tchem

Family: Enzyme

Novelty: 0.0019271

Score: 0.952

Data Source: STRINGDB

SRD5A2

Tclin

Family: Enzyme

Novelty: 0.00281044

Score: 0.952

Data Source: STRINGDB

HSD3B2

Tclin

Family: Enzyme

Novelty: 0.00711552

Score: 0.95

Data Source: STRINGDB

EPHX1

Tchem

Family: Enzyme

Novelty: 0.00220169

Score: 0.939

Data Source: STRINGDB

CYP1A1

Tchem

Novelty: 0.0002404

Score: 0.939

Data Source: STRINGDB

Publication Statistics

PubMed Score  237.96

PubMed score by year

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PubTator Score  278.22

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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NADP
Oxidoreductase
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