AKR1C1
Aldo-keto reductase family 1 member C1
Protein Summary
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
- ENST00000380872
- ENSP00000370254
- ENSG00000187134
- DDH
- DDH1
- C9
- DD1
- DDH
- DDH1
- H-37
- HBAB
- MBAB
- HAKRC
- DD1/DD2
- 2-ALPHA-HSD
- 20-ALPHA-HSD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
small molecule perturbation | 0.95 | ||
chemical | 0.91 | ||
transcription factor perturbation | 0.84 | ||
PubMedID | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.25 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.25 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 37
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (37)
Protein-Protein Interactions (71)
AKR1D1
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999899971
p_ni: 0.000067347
p_wrong: 0.000032682
Score: 0.986
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (10)
Upstream (4)
Downstream (6)
1 – 4 of 4
Pathways (21)
Reactome (16)
KEGG (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of fat-soluble vitamins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Metabolism | ||||
Metabolism of fat-soluble vitamins | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (14)
Components (2)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 3 | 4 | 95.6 | |||||
waist-hip ratio | 3 | 8 | 9 | 90.1 | |||||
BMI-adjusted waist-hip ratio | 3 | 6 | 7 | 86.1 | |||||
hip circumference | 1 | 5 | 5 | 73 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 63.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 4 | 95.6 | |||||
waist-hip ratio | 9 | 90.1 | |||||
BMI-adjusted waist-hip ratio | 7 | 86.1 | |||||
hip circumference | 5 | 73 | |||||
BMI-adjusted waist circumference | 2 | 63.6 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 242.25
PubMed score by year
PubTator Score 278.22
PubTator score by year
Related Publications
Text Mined References (70)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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