Protein Classes
Protein Summary
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors ar ...more
- ENST00000263640
- ENSP00000263640
- ENSG00000115170
- ENST00000409283
- ENSP00000387273
- ENST00000410057
- ENSP00000387127
- ENST00000434821
- ENSP00000405004
- ACVRLK2
- FOP
- ALK2
- SKR1
- TSRI
- ACTRI
- ACVR1A
- ACVRLK2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
biological process | 0.99 | ||
disease perturbation | 0.97 | ||
protein domain | 0.92 | ||
hub protein | 0.79 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 317.67 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 539 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 317.67 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 539 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (19)
1 – 10 of 19
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (192)
KEGG (4)
PathwayCommons (13)
WikiPathways (175)
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | TGF-beta signaling pathway | ||||
KEGG | Signaling pathways regulating pluripotency of stem cells | ||||
KEGG | Fluid shear stress and atherosclerosis | ||||
KEGG | Cytokine-cytokine receptor interaction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
TGF-beta signaling pathway | ||||
Signaling pathways regulating pluripotency of stem cells | ||||
Fluid shear stress and atherosclerosis | ||||
Cytokine-cytokine receptor interaction | ||||
Gene Ontology Terms (61)
Functions (15)
Components (4)
Processes (42)
Items per page:
10
1 – 10 of 15
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (115)
1 – 10 of 115
LRRIQ1
p_int: 0.999884701
p_ni: 0.000040716
p_wrong: 0.000074584
Score: 0.593
Data Source: BioPlex,STRINGDB
TNFRSF10A
Novelty: 0.0003938
p_int: 0.999864716
p_ni: 0.000077564
p_wrong: 0.00005772
Score: 0.663
Data Source: BioPlex,STRINGDB
TGFBRAP1
Novelty: 0.09004245
p_int: 0.963769973
p_ni: 0.03622065
p_wrong: 0.000009378
Score: 0.294
Data Source: BioPlex,STRINGDB
BMPR1A
Family: Kinase
Novelty: 0.00472897
p_int: 0.949442782
p_ni: 0.050554372
p_wrong: 0.000002846
Score: 0.933
Data Source: BioPlex,STRINGDB
BMPR2
Family: Kinase
Novelty: 0.00191079
p_int: 0.94729335
p_ni: 0.000047646
p_wrong: 0.052659005
Score: 0.991
Data Source: BioPlex,STRINGDB
RNF149
Family: Enzyme
Novelty: 0.47955733
p_int: 0.93758666
p_ni: 0.062223718
p_wrong: 0.000189622
Score: 0.643
Data Source: BioPlex,STRINGDB
MRAP2
Novelty: 0.05863056
p_int: 0.93482703
p_ni: 0.000051895
p_wrong: 0.065121075
Score: 0.531
Data Source: BioPlex,STRINGDB
GRAMD1A
Novelty: 0.3099631
p_int: 0.898234711
p_ni: 0.101765286
p_wrong: 2e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
ACVRL1
Family: Kinase
Novelty: 0.00374091
p_int: 0.874917456
p_ni: 8e-9
p_wrong: 0.125082536
Score: 0.546
Data Source: BioPlex,STRINGDB
CD320
Novelty: 0.03078608
p_int: 0.857411228
p_ni: 0.142587369
p_wrong: 0.000001402
Score: 0.739
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 317.67
PubMed score by year
PubTator Score 213.98
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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