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Tchem
GLO1
Lactoylglutathione lyase

Protein Summary
Description
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373365
  • ENSP00000362463
  • ENSG00000124767

Symbol
  • GLYI
  • GLOD1
  • HEL-S-74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.94
virus perturbation
0.88
disease
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.58   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 489.58   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (195)
1 – 10 of 195
TRPM4
Tchem
Family: IC
Novelty: 0.00423106
p_int: 0.999992813
p_ni: 0.000007181
p_wrong: 7e-9
Data Source: BioPlex
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.991686621
p_ni: 0.008313379
Data Source: BioPlex
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.982488452
p_ni: 0.017437511
p_wrong: 0.000074037
Score: 0.175
Data Source: BioPlex,STRINGDB
HAGH
Tbio
Family: Enzyme
Novelty: 0.00689153
Score: 0.997
Data Source: STRINGDB
GRHPR
Tbio
Family: Enzyme
Novelty: 0.01375508
Score: 0.956
Data Source: STRINGDB
PGP
Tbio
Family: Enzyme
Novelty: 0.0225528
Score: 0.89
Data Source: STRINGDB
PGM3
Tbio
Family: Enzyme
Novelty: 0.00515842
Score: 0.854
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.85
Data Source: STRINGDB
SDSL
Tbio
Family: Enzyme
Novelty: 0.02098867
Score: 0.836
Data Source: STRINGDB
SDS
Tbio
Family: Enzyme
Novelty: 0.00482255
Score: 0.836
Data Source: STRINGDB
Publication Statistics
PubMed Score  489.58

PubMed score by year
PubTator Score  593.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer