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Tchem
PRKCQ
Protein kinase C theta type

Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263125
  • ENSP00000263125
  • ENSG00000065675
  • ENST00000397176
  • ENSP00000380361
  • ENST00000539722
  • ENSP00000441752

Symbol
  • PRKCT
  • PRKCT
  • nPKC-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
hub protein
0.99
molecular function
0.96
gene perturbation
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.82   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 773   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.82   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 383
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ruboxistaurin
chemical structure image
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (97)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Axon guidance
Gene Ontology Terms (36)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (234)
1 – 10 of 234
DEF6
Tbio
Novelty: 0.00711772
p_int: 0.999904391
p_ni: 0.000095608
Score: 0.305
Data Source: BioPlex,STRINGDB
RYDEN
Tdark
Novelty: 0.11278195
p_int: 0.999828603
p_ni: 0.000163308
p_wrong: 0.000008089
Data Source: BioPlex
C2CD2L
Tbio
Novelty: 0.06105834
p_int: 0.997651134
p_ni: 0.002328853
p_wrong: 0.000020012
Score: 0.235
Data Source: BioPlex,STRINGDB
ZNF24
Tbio
Family: TF
Novelty: 0.02958008
p_int: 0.97575213
p_ni: 0.02424787
Score: 0.214
Data Source: BioPlex,STRINGDB
BCL10
Tbio
Novelty: 0.00196153
Score: 0.994
Data Source: Reactome,STRINGDB
CARD11
Tbio
Family: Enzyme
Novelty: 0.00699463
Score: 0.994
Data Source: Reactome,STRINGDB
MALT1
Tchem
Novelty: 0.00413584
Score: 0.994
Data Source: Reactome,STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00107685
Score: 0.988
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00425902
Score: 0.987
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00697684
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  152.82

PubMed score by year
PubTator Score  71.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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