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Tchem
PRKCQ
Protein kinase C theta type

Protein Classes
Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263125
  • ENSP00000263125
  • ENSG00000065675
  • ENST00000397176
  • ENSP00000380361
  • ENST00000539722
  • ENSP00000441752

Symbol
  • PRKCT
  • PRKCT
  • nPKC-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
hub protein
0.99
molecular function
0.96
gene perturbation
0.82


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.36   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 773   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.36   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 383
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ruboxistaurin
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
2
1
0
1.1
56.3
1
1
0
1
26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
56.3
0
1
26
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C theta
VGNC:7859
450288
Macaque
protein kinase C theta
722559
Mouse
MGI:97601
18761
Rat
RGD:620968
85420
Dog
protein kinase C theta
VGNC:44983
478013
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C theta
Macaque
protein kinase C theta
Mouse
Rat
Dog
protein kinase C theta
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (97)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Axon guidance
Gene Ontology Terms (36)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (234)
1 – 10 of 234
DEF6
Tbio
Novelty: 0.0378487
p_int: 0.999904391
p_ni: 0.000095608
Score: 0.305
Data Source: BioPlex,STRINGDB
RYDEN
Tdark
Novelty: 0.17308437
p_int: 0.999828603
p_ni: 0.000163308
p_wrong: 0.000008089
Data Source: BioPlex
C2CD2L
Tbio
Novelty: 0.2051681
p_int: 0.997651134
p_ni: 0.002328853
p_wrong: 0.000020012
Score: 0.235
Data Source: BioPlex,STRINGDB
ZNF24
Tbio
Family: TF
Novelty: 0.02954446
p_int: 0.97575213
p_ni: 0.02424787
Score: 0.214
Data Source: BioPlex,STRINGDB
BCL10
Tbio
Novelty: 0.00253704
Score: 0.994
Data Source: Reactome,STRINGDB
CARD11
Tbio
Family: Enzyme
Novelty: 0.00716457
Score: 0.994
Data Source: Reactome,STRINGDB
MALT1
Tchem
Novelty: 0.00367231
Score: 0.994
Data Source: Reactome,STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
Score: 0.988
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.987
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  141.36

PubMed score by year
PubTator Score  71.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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