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Tchem
HGFAC
Hepatocyte growth factor activator

Protein Summary
Description
Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382774
  • ENSP00000372224
  • ENSG00000109758

Symbol
  • HGFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.61
cell line
0.59
co-expressed gene
0.52
tissue sample
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.52   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.52   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nafamostat
chemical structure image
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
4
98.3
sex hormone-binding globulin measurement
6
1
6
98.2
low density lipoprotein cholesterol measurement
3
1
3
97.2
hepatocyte growth factor measurement
3
3
2
28.8
93.6
triglyceride measurement
7
3
11
92.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
98.3
sex hormone-binding globulin measurement
6
98.2
low density lipoprotein cholesterol measurement
3
97.2
hepatocyte growth factor measurement
2
28.8
93.6
triglyceride measurement
11
92.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HGF activator
VGNC:611
107974156
Macaque
HGF activator
719952
Mouse
MGI:1859281
54426
Rat
RGD:70909
58947
Dog
HGF activator
VGNC:41675
403432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HGF activator
Macaque
HGF activator
Mouse
Rat
Dog
HGF activator
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
MET Receptor Activation (R-HSA-6806942)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET Receptor Activation
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET Receptor Activation
Signal Transduction
Signaling by MET
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (88)
1 – 10 of 88
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.999907921
p_ni: 0.000008815
p_wrong: 0.000083264
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.994279497
p_ni: 0.00001035
p_wrong: 0.005710154
Score: 0.245
Data Source: BioPlex,STRINGDB
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.994243596
p_ni: 0.000003827
p_wrong: 0.005752577
Score: 0.881
Data Source: BioPlex,STRINGDB
SERPINA5
Tbio
Family: Enzyme
Novelty: 0.00152504
p_int: 0.994200579
p_ni: 0.000003624
p_wrong: 0.005795797
Score: 0.48
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.974601219
p_ni: 0.025398779
p_wrong: 2e-9
Score: 0.166
Data Source: BioPlex,STRINGDB
APBB3
Tbio
Novelty: 0.15864948
p_int: 0.941548212
p_ni: 0.000058724
p_wrong: 0.058393065
Data Source: BioPlex
APBB2
Tbio
Novelty: 0.06546724
p_int: 0.935294586
p_ni: 0.000014071
p_wrong: 0.064691343
Score: 0.171
Data Source: BioPlex,STRINGDB
RAE1
Tbio
Novelty: 0.01342883
p_int: 0.93147339
p_ni: 0.06852661
Data Source: BioPlex
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.916838883
p_ni: 0.067610901
p_wrong: 0.015550216
Data Source: BioPlex
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.840932217
p_ni: 0.159065664
p_wrong: 0.000002119
Data Source: BioPlex
Publication Statistics
PubMed Score  129.52

PubMed score by year
PubTator Score  74.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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