Tchem HGFAC Hepatocyte growth factor activator

Protein Summary

Description

Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q04756
• Q14726
• Q2M1W7
• Q53X47
• HGF activator

Gene Name

• HGFAC

Ensembl ID

• ENST00000382774
• ENSP00000372224
• ENSG00000109758

Symbol

• HGFA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
gene perturbation	0.61
cell line	0.59
co-expressed gene	0.52
tissue sample	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Hepatocyte Growth Factor Activator

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Hepatocyte Growth Factor Activator

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.93   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.93   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1