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Tbio
TLE4
Transducin-like enhancer protein 4

Protein Summary
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265284
  • ENSP00000265284
  • ENSG00000106829
  • ENST00000376537
  • ENSP00000365720
  • ENST00000376544
  • ENSP00000365727
  • ENST00000376552
  • ENSP00000365735

Symbol
  • GRG4
  • KIAA1261
  • ESG
  • BCE1
  • ESG4
  • GRG4
  • BCE-1
  • Grg-4
  • E(spI)
  • E(spl)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
PubMedID
0.93
transcription factor binding site profile
0.9
transcription factor
0.87
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
89.2
balding measurement
1
2
2
69.6
platelet crit
1
1
1
64
platelet count
1
1
1
61
self reported educational attainment
1
1
1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
89.2
balding measurement
2
69.6
platelet crit
1
64
platelet count
1
61
self reported educational attainment
1
59.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 4
VGNC:8941
464544
Macaque
transducin-like enhancer protein 4
706619
Mouse
MGI:104633
21888
Rat
RGD:3868
25565
Dog
transducin like enhancer of split 4
VGNC:53997
476317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 4
Macaque
transducin-like enhancer protein 4
Mouse
Rat
Dog
transducin like enhancer of split 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04727-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
NOTCH1 Intracellular Domain Regulates Transcription
Reactome
Repression of WNT target genes
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Repression of WNT target genes
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (133)
1 – 10 of 133
AES
Tbio
Novelty:  0.00818499
p_int:  1
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  1
Score:  0.901
Data Source:  BioPlex,Reactome,STRINGDB
RIPPLY1
Tdark
Novelty:  0.11705603
p_int:  0.999999995
p_ni:  5e-9
Score:  0.757
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.99999997
p_ni:  3.1e-8
Score:  0.901
Data Source:  BioPlex,Reactome,STRINGDB
RIPPLY2
Tdark
Novelty:  0.16163153
p_int:  0.999999968
p_ni:  3.2e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999999349
p_ni:  6.51e-7
Data Source:  BioPlex
TLE2
Tbio
Novelty:  0.03922169
p_int:  0.999990708
p_ni:  0.00000917
p_wrong:  1.23e-7
Score:  0.902
Data Source:  BioPlex,Reactome,STRINGDB
TBX20
Tbio
Family:  TF
Novelty:  0.01290983
p_int:  0.999673718
p_ni:  0.000326282
Score:  0.514
Data Source:  BioPlex,STRINGDB
HLX
Tbio
Family:  TF
Novelty:  0.00982861
p_int:  0.999652562
p_ni:  0.000347438
Score:  0.572
Data Source:  BioPlex,STRINGDB
TNNI2
Tbio
Novelty:  0.02772952
p_int:  0.995455479
p_ni:  0.004544521
Score:  0.188
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.81

PubMed score by year
PubTator Score  28.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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