You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TLE3
Transducin-like enhancer protein 3

Protein Summary
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317509
  • ENSP00000319233
  • ENSG00000140332
  • ENST00000440567
  • ENSP00000415057
  • ENST00000451782
  • ENSP00000394717
  • ENST00000557907
  • ENSP00000453107
  • ENST00000557997
  • ENSP00000453083
  • ENST00000558379
  • ENSP00000453435
  • ENST00000558939
  • ENSP00000452871
  • ENST00000559048
  • ENSP00000453760

Symbol
  • KIAA1547
  • ESG
  • ESG3
  • GRG3
  • HsT18976
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
transcription factor binding site profile
0.99
transcription factor perturbation
0.99
kinase perturbation
0.93
PubMedID
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0