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Tbio
TLE2
Transducin-like enhancer protein 2

Protein Summary
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262953
  • ENSP00000262953
  • ENSG00000065717
  • ENST00000426948
  • ENSP00000392869
  • ENST00000443826
  • ENSP00000392427
  • ENST00000455444
  • ENSP00000413107
  • ENST00000591529
  • ENSP00000468279

Symbol
  • ESG
  • ESG2
  • GRG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
virus perturbation
0.72
gene perturbation
0.68
PubMedID
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
79.5
1
1
0
25
78.6
1
1
0
50
76.5
2
1
0
1.1
47.7
calcium measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
79.5
0
25
78.6
0
50
76.5
0
1.1
47.7
calcium measurement
1
46.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 2
VGNC:3593
456381
Macaque
transducin like enhancer of split 2
721644
Mouse
MGI:104635
21886
Rat
RGD:1306665
299636
Dog
transducin like enhancer of split 2
100687252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 2
Macaque
transducin like enhancer of split 2
Mouse
Rat
Dog
transducin like enhancer of split 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04725-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
NOTCH1 Intracellular Domain Regulates Transcription
Reactome
Repression of WNT target genes
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Repression of WNT target genes
Protein-Protein Interactions (100)
1 – 10 of 100
RIPPLY1
Tdark
Novelty:  0.11705603
p_int:  0.999999978
p_ni:  1.5e-8
p_wrong:  7e-9
Score:  0.364
Data Source:  BioPlex,STRINGDB
RIPPLY2
Tdark
Novelty:  0.16163153
p_int:  0.999999895
p_ni:  1.04e-7
p_wrong:  1e-9
Score:  0.273
Data Source:  BioPlex,STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999999736
p_ni:  2.64e-7
Data Source:  BioPlex
AES
Tbio
Novelty:  0.00818499
p_int:  0.999998861
p_ni:  0.000001139
Score:  0.908
Data Source:  BioPlex,Reactome,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999995191
p_ni:  0.000004808
p_wrong:  1e-9
Score:  0.928
Data Source:  BioPlex,Reactome,STRINGDB
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999990708
p_ni:  0.00000917
p_wrong:  1.23e-7
Score:  0.902
Data Source:  BioPlex,Reactome,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999975301
p_ni:  0.000023148
p_wrong:  0.000001552
Score:  0.902
Data Source:  BioPlex,Reactome,STRINGDB
HLX
Tbio
Family:  TF
Novelty:  0.00982861
p_int:  0.999897043
p_ni:  0.000102955
p_wrong:  1e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.975007885
p_ni:  0.024992115
Data Source:  BioPlex
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.943298359
p_ni:  0.056701641
Data Source:  BioPlex
Publication Statistics
PubMed Score  26.22

PubMed score by year
PubTator Score  21.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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