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Tchem
NOTCH2
Neurogenic locus notch homolog protein 2

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256646
  • ENSP00000256646
  • ENSG00000134250

Symbol
  • hN2
  • AGS2
  • HJCYS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
microRNA
0.97
kinase perturbation
0.96
cellular component
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.2   (req: < 5)
Gene RIFs: 172   (req: <= 3)
Antibodies: 596   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.2   (req: >= 5)
Gene RIFs: 172   (req: > 3)
Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (212)
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.999991275
p_ni:  0.000008725
Score:  0.274
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999819087
p_ni:  0.000180913
Data Source:  BioPlex
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.998881251
p_ni:  0.001118749
Score:  0.16
Data Source:  BioPlex,STRINGDB
VASN
Tbio
Novelty:  0.05424159
p_int:  0.997817037
p_ni:  0.002182963
Score:  0.18
Data Source:  BioPlex,STRINGDB
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.979286285
p_ni:  0.020713715
Score:  0.292
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.975872517
p_ni:  0.024127483
Data Source:  BioPlex
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
p_int:  0.955686981
p_ni:  0.044313019
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.939366431
p_ni:  0.060633569
Score:  0.197
Data Source:  BioPlex,STRINGDB
AGRP
Tbio
Novelty:  0.00147804
p_int:  0.877034491
p_ni:  0.122965509
Score:  0.228
Data Source:  BioPlex,STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.999
Data Source:  Reactome,STRINGDB
Pathways (48)
Defective LFNG causes SCDO3 (R-HSA-5083630)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LFNG causes SCDO3
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Defective LFNG causes SCDO3
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
3
1.1
91.7
leukocyte count
1
1
1
81.7
serum gamma-glutamyl transferase measurement
1
1
1
64.9
2
2
0
1.1
53.7
lymphocyte count
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
91.7
leukocyte count
1
81.7
serum gamma-glutamyl transferase measurement
1
64.9
0
1.1
53.7
lymphocyte count
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 504.20
PubMed score by year
PubTator Score 318.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title