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Tbio
KRT17
Keratin, type I cytoskeletal 17

Protein Summary
Description
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions bein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311208
  • ENSP00000308452
  • ENSG00000128422
  • ENST00000648886
  • ENSP00000497796

Symbol
  • PC
  • K17
  • PC2
  • 39.1
  • CK-17
  • PCHC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
interacting protein
0.94
gene perturbation
0.9
disease
0.84
small molecule perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.45   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 1064   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.45   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 1064   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.974
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.968
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.968
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.967
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.963
Data Source:  STRINGDB
KRT7
Tbio
Novelty:  0.00039796
Score:  0.955
Data Source:  STRINGDB
KRT8
Tbio
Novelty:  0.00093008
Score:  0.953
Data Source:  STRINGDB
KRT72
Tbio
Novelty:  0.06391566
Score:  0.951
Data Source:  STRINGDB
KRT1
Tbio
Novelty:  0.00278467
Score:  0.946
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 17
VGNC:12354
468261
Macaque
keratin 14 [Source:HGNC Symbol;Acc:HGNC:6416]
Mouse
MGI:96691
16667
Rat
RGD:1303181
287702
Dog
keratin 17
490977
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 17
Macaque
keratin 14 [Source:HGNC Symbol;Acc:HGNC:6416]
Mouse
Rat
Dog
keratin 17
Publication Statistics
PubMed Score 358.45
PubMed score by year
PubTator Score 279.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title