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Tbio
ATP7A
Copper-transporting ATPase 1

Protein Summary
Description
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341514
  • ENSP00000345728
  • ENSG00000165240
  • ENST00000343533
  • ENSP00000343026

Symbol
  • MC1
  • MNK
  • MK
  • MNK
  • DSMAX
  • SMAX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.99
disease perturbation
0.9
disease
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1927.71   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1927.71   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999999594
p_ni:  4.05e-7
p_wrong:  1e-9
Data Source:  BioPlex
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.999974884
p_ni:  0.000025099
p_wrong:  1.7e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
COG5
Tbio
Novelty:  0.04017657
p_int:  0.999564483
p_ni:  0.000435517
Score:  0.315
Data Source:  BioPlex,STRINGDB
CD83
Tbio
Novelty:  0.00138653
p_int:  0.999356708
p_ni:  0.000643292
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999273303
p_ni:  0.000726232
p_wrong:  4.64e-7
Data Source:  BioPlex
SLC9A3R2
Tchem
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999160029
p_ni:  0.000838628
p_wrong:  0.000001342
Data Source:  BioPlex
TMEM130
Tdark
Novelty:  1.39618601
p_int:  0.999030504
p_ni:  0.000969479
p_wrong:  1.7e-8
Data Source:  BioPlex
RPS27
Tchem
Novelty:  0.02805495
p_int:  0.998691719
p_ni:  0.001308263
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.997062768
p_ni:  0.002937191
p_wrong:  4.2e-8
Data Source:  BioPlex
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.996138095
p_ni:  0.003859102
p_wrong:  0.000002804
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (90)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
81.5
mean platelet volume
1
1
1
51
body weight
1
1
1
48.8
erythrocyte count
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
81.5
mean platelet volume
1
51
body weight
1
48.8
erythrocyte count
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase copper transporting alpha
VGNC:7633
100612635
Mouse
MGI:99400
11977
Rat
RGD:2179
24941
Dog
ATPase copper transporting alpha
VGNC:38285
406185
Horse
ATPase copper transporting alpha
VGNC:15684
100071762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase copper transporting alpha
Mouse
Rat
Dog
ATPase copper transporting alpha
Horse
ATPase copper transporting alpha
Publication Statistics
PubMed Score 1927.71
PubMed score by year
PubTator Score 366.83
PubTator score by year
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Related Publications
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PMID
Year
Title