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Tbio
EIF4G1
Eukaryotic translation initiation factor 4 gamma 1

Protein Summary
Description
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342981
  • ENSP00000343450
  • ENSG00000114867
  • ENST00000346169
  • ENSP00000316879
  • ENST00000350481
  • ENSP00000317600
  • ENST00000352767
  • ENSP00000338020
  • ENST00000382330
  • ENSP00000371767
  • ENST00000392537
  • ENSP00000376320
  • ENST00000414031
  • ENSP00000391935
  • ENST00000424196
  • ENSP00000416255
  • ENST00000434061
  • ENSP00000411826
  • ENST00000435046
  • ENSP00000404754

Symbol
  • EIF4F
  • EIF4G
  • EIF4GI
  • P220
  • EIF4F
  • EIF4G
  • EIF4GI
  • PARK18
  • EIF-4G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
kinase perturbation
1
disease perturbation
0.97
ligand (protein) perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.75   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.75   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
57.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
57.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4 gamma 1
VGNC:7969
460888
Macaque
eukaryotic translation initiation factor 4 gamma 1
704923
Mouse
MGI:2384784
208643
Rat
RGD:1306144
287986
Dog
eukaryotic translation initiation factor 4 gamma 1
VGNC:40289
100688785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4 gamma 1
Macaque
eukaryotic translation initiation factor 4 gamma 1
Mouse
Rat
Dog
eukaryotic translation initiation factor 4 gamma 1
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Name
Explore in Pharos
Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Antiviral mechanism by IFN-stimulated genes
Axon guidance
Cap-dependent Translation Initiation
Gene Ontology Terms (45)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Protein-Protein Interactions (442)
1 – 10 of 442
EIF4A1
Tchem
Novelty: 0.00269994
p_int: 0.999999309
p_ni: 6.91e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4E
Tchem
Novelty: 0.00072182
p_int: 0.999983917
p_ni: 0.000016083
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
IFT22
Tbio
Family: Enzyme
Novelty: 0.18342877
p_int: 0.983894854
p_ni: 0.016105146
Data Source: BioPlex
GCHFR
Tbio
Family: Enzyme
Novelty: 0.04287433
p_int: 0.978821114
p_ni: 0.021178886
Score: 0.188
Data Source: BioPlex,STRINGDB
EIF3I
Tbio
Novelty: 0.04398155
p_int: 0.957852466
p_ni: 0.042147534
Score: 0.981
Data Source: BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty: 0.02974299
p_int: 0.928115395
p_ni: 0.071884605
Score: 0.324
Data Source: BioPlex,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.918104561
p_ni: 0.081895439
Data Source: BioPlex
MAMDC2
Tdark
Novelty: 0.22933145
p_int: 0.780046337
p_ni: 0.219953663
Score: 0.29
Data Source: BioPlex,STRINGDB
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.999
Data Source: Reactome,STRINGDB
EIF4B
Tbio
Novelty: 0.00665561
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  560.75

PubMed score by year
PubTator Score  526.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer