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Tbio
EIF4G1
Eukaryotic translation initiation factor 4 gamma 1

Protein Summary
Description
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342981
  • ENSP00000343450
  • ENSG00000114867
  • ENST00000346169
  • ENSP00000316879
  • ENST00000350481
  • ENSP00000317600
  • ENST00000352767
  • ENSP00000338020
  • ENST00000382330
  • ENSP00000371767
  • ENST00000392537
  • ENSP00000376320
  • ENST00000414031
  • ENSP00000391935
  • ENST00000424196
  • ENSP00000416255
  • ENST00000434061
  • ENSP00000411826
  • ENST00000435046
  • ENSP00000404754

Symbol
  • EIF4F
  • EIF4G
  • EIF4GI
  • P220
  • EIF4F
  • EIF4G
  • EIF4GI
  • PARK18
  • EIF-4G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
kinase perturbation
1
disease perturbation
0.97
ligand (protein) perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.79   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 542   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.79   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0