EIF4G1
Eukaryotic translation initiation factor 4 gamma 1
Protein Summary
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
- ENST00000342981
- ENSP00000343450
- ENSG00000114867
- ENST00000346169
- ENSP00000316879
- ENST00000350481
- ENSP00000317600
- ENST00000352767
- ENSP00000338020
- ENST00000382330
- ENSP00000371767
- ENST00000392537
- ENSP00000376320
- ENST00000414031
- ENSP00000391935
- ENST00000424196
- ENSP00000416255
- ENST00000434061
- ENSP00000411826
- ENST00000435046
- ENSP00000404754
- EIF4F
- EIF4G
- EIF4GI
- P220
- EIF4F
- EIF4G
- EIF4GI
- PARK18
- EIF-4G1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
disease perturbation | 0.97 | ||
ligand (protein) perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 628.79 (req: < 5)
Gene RIFs: 119 (req: <= 3)
Antibodies: 542 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 628.79 (req: >= 5)
Gene RIFs: 119 (req: > 3)
Antibodies: 542 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0