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Tchem
FOLH1
Glutamate carboxypeptidase 2

Protein Summary
Description
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and cons ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256999
  • ENSP00000256999
  • ENSG00000086205
  • ENST00000340334
  • ENSP00000344131
  • ENST00000356696
  • ENSP00000349129
  • ENST00000533034
  • ENSP00000431463

Symbol
  • FOLH
  • NAALAD1
  • PSM
  • PSMA
  • PSM
  • FGCP
  • FOLH
  • GCP2
  • PSMA
  • mGCP
  • GCPII
  • NAALAD1
  • NAALAdase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
cellular component
0.69
tissue
0.68
kinase perturbation
0.66
disease
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4073.26   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 1127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4073.26   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 1127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 191
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
42.1
1
1
1
2.2
high density lipoprotein cholesterol measurement
1
1
1
0.4
alcohol drinking
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
42.1
1
2.2
high density lipoprotein cholesterol measurement
1
0.4
alcohol drinking
1
0.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
folate hydrolase 1B
451475
Macaque
folate hydrolase 1B
707714
Mouse
MGI:1858193
53320
Rat
RGD:70963
85309
Dog
folate hydrolase (prostate-specific membrane antigen) 1
476775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
folate hydrolase 1B
Macaque
folate hydrolase 1B
Mouse
Rat
Dog
folate hydrolase (prostate-specific membrane antigen) 1
Protein Structure (67 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q04609-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 67
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (84)
1 – 10 of 84
RIMKLB
Tbio
Family: Enzyme
Novelty: 0.17814588
Score: 0.961
Data Source: STRINGDB
RIMKLA
Tdark
Family: Enzyme
Novelty: 0.30213465
Score: 0.955
Data Source: STRINGDB
ASPA
Tbio
Family: Enzyme
Novelty: 0.02701619
Score: 0.927
Data Source: STRINGDB
NAT8L
Tbio
Family: Enzyme
Novelty: 0.01761988
Score: 0.922
Data Source: STRINGDB
KLK3
Tchem
Family: Enzyme
Novelty: 0.00003606
Score: 0.868
Data Source: STRINGDB
PSCA
Tbio
Novelty: 0.00323778
Score: 0.743
Data Source: STRINGDB
DPP4
Tclin
Family: Enzyme
Novelty: 0.00017047
Score: 0.732
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.722
Data Source: STRINGDB
SMUG1
Tbio
Family: Enzyme
Novelty: 0.01345774
Score: 0.67
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  4073.26

PubMed score by year
PubTator Score  1552.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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