Tclin FOLH1 Glutamate carboxypeptidase 2

Protein Summary

Description

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q04609
• A4UU12
• A9CB79
• B7Z312
• B7Z343
• D3DQS5
• E9PDX8
• O43748
• Q16305
• Q541A4
• Q8TAY3
• Q9NP15
• Q9NYE2
• Q9P1P8

Gene Name

• FOLH1

Ensembl ID

• ENST00000256999
• ENSP00000256999
• ENSG00000086205
• ENST00000340334
• ENSP00000344131
• ENST00000356696
• ENSP00000349129
• ENST00000533034
• ENSP00000431463

Symbol

• FOLH
• NAALAD1
• PSM
• PSMA
• PSM
• FGCP
• FOLH
• GCP2
• PSMA
• mGCP
• GCPII
• NAALAD1
• NAALAdase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.83
cellular component	0.69
tissue	0.68
kinase perturbation	0.66
disease	0.62

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Glutamate Carboxypeptidase 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Glutamate Carboxypeptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5660.66   (req: < 5)

Gene RIFs: 154   (req: <= 3)

Antibodies: 1127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5660.66   (req: >= 5)

Gene RIFs: 154   (req: > 3)

Antibodies: 1127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 240

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1