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Tbio
UBXN1
UBX domain-containing protein 1

Protein Summary
Description
Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhib ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294119
  • ENSP00000294119
  • ENSG00000162191
  • ENST00000301935
  • ENSP00000303991

Symbol
  • SAKS1
  • 2B28
  • SAKS1
  • UBXD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.84
histone modification site profile
0.8
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.41   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
5
5
90.1
BMI-adjusted waist-hip ratio
2
6
6
90
forced expiratory volume
1
1
1
78.3
waist circumference
1
3
3
75.9
vital capacity
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
90.1
BMI-adjusted waist-hip ratio
6
90
forced expiratory volume
1
78.3
waist circumference
3
75.9
vital capacity
1
73.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 1
VGNC:953
451261
Macaque
UBX domain protein 1
718643
Mouse
MGI:1289301
225896
Rat
RGD:1309471
293719
Dog
UBX domain protein 1
VGNC:48095
476055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 1
Macaque
UBX domain protein 1
Mouse
Rat
Dog
UBX domain protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04323-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein modification
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
MID2
Tbio
Family:  Enzyme
Novelty:  0.01349913
p_int:  0.999999663
p_ni:  3.34e-7
p_wrong:  3e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999999595
p_ni:  4.05e-7
Data Source:  BioPlex
TNFAIP1
Tbio
Novelty:  0.04006419
p_int:  0.999866886
p_ni:  0.000116193
p_wrong:  0.000016921
Score:  0.828
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.999182972
p_ni:  0.000817028
Score:  0.854
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.994181171
p_ni:  0.005818829
Data Source:  BioPlex
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.992137153
p_ni:  0.007862843
p_wrong:  4e-9
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.991760553
p_ni:  0.008239415
p_wrong:  3.2e-8
Data Source:  BioPlex
TCAF1
Tbio
Family:  Enzyme
Novelty:  0.50366212
p_int:  0.989219943
p_ni:  0.010780057
Score:  0.519
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.983320771
p_ni:  0.016677622
p_wrong:  0.000001607
Data Source:  BioPlex
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.981164002
p_ni:  0.018749236
p_wrong:  0.000086762
Data Source:  BioPlex
Publication Statistics
PubMed Score  10.41

PubMed score by year
PubTator Score  4.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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