You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RELA
Transcription factor p65

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308639
  • ENSP00000311508
  • ENSG00000173039
  • ENST00000406246
  • ENSP00000384273

Symbol
  • NFKB3
  • p65
  • CMCU
  • NFKB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.94   (req: < 5)
Gene RIFs: 861   (req: <= 3)
Antibodies: 3431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.94   (req: >= 5)
Gene RIFs: 861   (req: > 3)
Antibodies: 3431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 101
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2