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Tbio
HSF2
Heat shock factor protein 2

Protein Summary
Description
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368455
  • ENSP00000357440
  • ENSG00000025156
  • ENST00000452194
  • ENSP00000400380

Symbol
  • HSTF2
  • HSF 2
  • HSTF 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.73
transcription factor perturbation
0.68
transcription factor binding site profile
0.66
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.53   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.53   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
82.4
myeloid white cell count
1
1
1
78.6
monocyte count
1
1
1
52.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
82.4
myeloid white cell count
1
78.6
monocyte count
1
52.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock transcription factor 2
VGNC:3121
462974
Macaque
heat shock transcription factor 2
713938
Mouse
MGI:96239
15500
Rat
RGD:68395
64441
Dog
heat shock transcription factor 2
VGNC:41815
476276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock transcription factor 2
Macaque
heat shock transcription factor 2
Mouse
Rat
Dog
heat shock transcription factor 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03933-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
HSF1
Tchem
Family: TF
Novelty: 0.00450276
p_int: 0.99999995
p_ni: 5e-8
Score: 0.865
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.999997478
p_ni: 0.000002522
Score: 0.524
Data Source: BioPlex,STRINGDB
SCEL
Tbio
Novelty: 0.03037518
p_int: 0.999986469
p_ni: 0.000005265
p_wrong: 0.000008266
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999982474
p_ni: 0.000017525
p_wrong: 1e-9
Score: 0.479
Data Source: BioPlex,STRINGDB
SPRR3
Tbio
Novelty: 0.0241484
p_int: 0.999982301
p_ni: 0.000017481
p_wrong: 2.17e-7
Data Source: BioPlex
CRNN
Tbio
Novelty: 0.01648731
p_int: 0.999970094
p_ni: 0.000029906
Data Source: BioPlex
DSG3
Tbio
Novelty: 0.0019802
p_int: 0.999962372
p_ni: 0.000019666
p_wrong: 0.000017962
Data Source: BioPlex
GBP6
Tbio
Novelty: 0.11644462
p_int: 0.999903236
p_ni: 0.00009242
p_wrong: 0.000004344
Data Source: BioPlex
PPL
Tbio
Novelty: 0.00684645
p_int: 0.999804909
p_ni: 0.000195091
Data Source: BioPlex
WDR5B
Tdark
Novelty: 1.29746249
p_int: 0.999448669
p_ni: 0.000550755
p_wrong: 5.75e-7
Score: 0.264
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.53

PubMed score by year
PubTator Score  85.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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