Tclin KCNC4 Potassium voltage-gated channel subfamily C member 4

Protein Summary

Description

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q03721
• Q3MIM4
• Q5TBI6

Gene Name

• KCNC4

Ensembl ID

• ENST00000369787
• ENSP00000358802
• ENSG00000116396
• ENST00000438661
• ENSP00000393655
• ENST00000469655
• ENSP00000436656

Symbol

• C1orf30
• KV3.4
• C1orf30
• KSHIIIC
• HKSHIIIC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.79
microRNA	0.74
transcription factor perturbation	0.74
gene perturbation	0.73

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / C (Shaw) Subfamily / Kv3.4/kcnc4 Sub-subfamily / Potassium Voltage-gated Channel Subfamily C Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.07   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 296   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.07   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4