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Tbio
CEBPZ
CCAAT/enhancer-binding protein zeta

Protein Summary
Description
Stimulates transcription from the HSP70 promoter. This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234170
  • ENSP00000234170
  • ENSG00000115816

Symbol
  • CBF2
  • CBF
  • CBF2
  • NOC1
  • HSP-CBF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
drug perturbation
0.87
molecular function
0.81
hub protein
0.79
kinase perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCAAT enhancer binding protein zeta
VGNC:189
459156
Macaque
CCAAT/enhancer binding protein zeta
712090
Mouse
MGI:109386
12607
Rat
RGD:1304994
362686
Dog
CCAAT enhancer binding protein zeta
VGNC:39090
483035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCAAT enhancer binding protein zeta
Macaque
CCAAT/enhancer binding protein zeta
Mouse
Rat
Dog
CCAAT enhancer binding protein zeta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q03701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (252)
1 – 10 of 252
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.999971902
p_ni: 0.000028097
p_wrong: 1e-9
Score: 0.319
Data Source: BioPlex,STRINGDB
NOC2L
Tbio
Novelty: 0.00226536
p_int: 0.999166837
p_ni: 0.000833163
Score: 0.998
Data Source: BioPlex,STRINGDB
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.997101024
p_ni: 0.002898976
Score: 0.897
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.993953044
p_ni: 0.006046956
Score: 0.916
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.988081556
p_ni: 0.011918438
p_wrong: 6e-9
Score: 0.216
Data Source: BioPlex,STRINGDB
FMR1NB
Tbio
Novelty: 0.1016511
p_int: 0.987570466
p_ni: 0.012429531
p_wrong: 3e-9
Score: 0.198
Data Source: BioPlex,STRINGDB
RPS14
Tbio
Novelty: 0.00576737
p_int: 0.979384228
p_ni: 0.020615772
Data Source: BioPlex
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.971239189
p_ni: 0.028760811
Score: 0.94
Data Source: BioPlex,STRINGDB
RSBN1
Tbio
Novelty: 0.1955858
p_int: 0.956006031
p_ni: 0.043993969
Score: 0.531
Data Source: BioPlex,STRINGDB
FGF8
Tbio
Novelty: 0.00155113
p_int: 0.95317055
p_ni: 0.046829446
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  123.84

PubMed score by year
PubTator Score  262.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer