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Tbio
COL10A1
Collagen alpha-1(X) chain

Protein Summary
Description
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243222
  • ENSP00000243222
  • ENSG00000123500
  • ENST00000327673
  • ENSP00000327368
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
small molecule perturbation
0.59
phenotype
0.54
biological term
0.53
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.48   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.48   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
6.5
81.6
Myopia
2
1
0
3.8
50.4
1
1
0
1.1
38.2
age at onset
1
1
0
6.5
33.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
6.5
81.6
Myopia
0
3.8
50.4
0
1.1
38.2
age at onset
0
6.5
33.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type X alpha 1 chain
VGNC:10661
742603
Mouse
MGI:88445
12813
Rat
RGD:2371
25681
Dog
collagen type X alpha 1 chain
VGNC:39455
100856711
Horse
collagen type X alpha 1 chain
VGNC:16720
100066959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type X alpha 1 chain
Mouse
Rat
Dog
collagen type X alpha 1 chain
Horse
collagen type X alpha 1 chain
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03692-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Protein-Protein Interactions (135)
1 – 10 of 135
C1QL4
Tdark
Novelty: 0.37071722
p_int: 0.999586311
p_ni: 0.000413689
Score: 0.202
Data Source: BioPlex,STRINGDB
C1QL1
Tdark
Novelty: 0.11689088
p_int: 0.999474253
p_ni: 0.000520165
p_wrong: 0.000005583
Score: 0.18
Data Source: BioPlex,STRINGDB
TOMM34
Tbio
Novelty: 0.05433718
p_int: 0.990880095
p_ni: 0.009119905
Score: 0.188
Data Source: BioPlex,STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.938605623
p_ni: 0.061393753
p_wrong: 6.23e-7
Score: 0.929
Data Source: BioPlex,STRINGDB
NUMB
Tbio
Novelty: 0.00211228
p_int: 0.935987305
p_ni: 0.064002708
p_wrong: 0.000009988
Score: 0.214
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
p_int: 0.905750056
p_ni: 0.094249318
p_wrong: 6.26e-7
Score: 0.961
Data Source: BioPlex,STRINGDB
MPP1
Tbio
Novelty: 0.08674817
p_int: 0.862834343
p_ni: 0.135630803
p_wrong: 0.001534854
Score: 0.305
Data Source: BioPlex,STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.935
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.932
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  176.48

PubMed score by year
PubTator Score  102.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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