Tbio TAP2 Antigen peptide transporter 2

Protein Summary

Description

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q03519
• B0V2J8
• O95410
• Q53FI6
• Q5HY71
• Q96PT8
• Q9UQ83
• APT2

Gene Name

• TAP2

Ensembl ID

• ENST00000374897
• ENSP00000364032
• ENSG00000204267
• ENST00000374899
• ENSP00000364034
• ENST00000383118
• ENSP00000372599
• ENSG00000206235
• ENST00000383119
• ENSP00000372600
• ENST00000383239
• ENSP00000372726
• ENSG00000206299
• ENST00000383240
• ENSP00000372727
• ENST00000414145
• ENSP00000401377
• ENSG00000228582
• ENST00000419142
• ENSP00000390013
• ENSG00000237599
• ENST00000426977
• ENSP00000387553
• ENSG00000232326
• ENST00000439425
• ENSP00000396156
• ENSG00000225967
• ENST00000443713
• ENSP00000394101
• ENST00000451907
• ENSP00000392172
• ENSG00000223481

Symbol

• ABCB3
• PSF2
• RING11
• Y1
• APT2
• PSF2
• ABC18
• ABCB3
• PSF-2
• RING11
• D6S217E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	0.97
protein domain	0.92
interacting protein	0.86
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Antigen Peptide Transporter 2

Protein / ... / Cysteine Protease / Antigen Peptide Transporter 2

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcb Subfamily / Antigen Peptide Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.87   (req: < 5)

Gene RIFs: 104   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.87   (req: >= 5)

Gene RIFs: 104   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0