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Tbio
TAP1
Antigen peptide transporter 1

Protein Summary
Description
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354258
  • ENSP00000346206
  • ENSG00000168394
  • ENST00000383235
  • ENSP00000372722
  • ENSG00000206297
  • ENST00000414467
  • ENSP00000405356
  • ENSG00000226173
  • ENST00000418205
  • ENSP00000401149
  • ENSG00000227816
  • ENST00000424897
  • ENSP00000413080
  • ENSG00000230705
  • ENST00000439781
  • ENSP00000415660
  • ENSG00000224212
  • ENST00000440894
  • ENSP00000402316
  • ENSG00000232367

Symbol
  • ABCB2
  • PSF1
  • RING4
  • Y3
  • APT1
  • PSF1
  • ABC17
  • ABCB2
  • PSF-1
  • RING4
  • TAP1N
  • D6S114E
  • TAP1*0102N
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
virus perturbation
1
transcription factor perturbation
0.94
protein domain
0.92
biological term
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.26   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (287)
Items per page:
1 – 5 of 287
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
1.1
90
Eczema
1
5
0
1.1
90
1
5
0
1.1
90
Eczema
1
5
0
1.1
90
1
5
0
1.1
90
Items per page:
1 – 5 of 287
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90
Eczema
0
1.1
90
0
1.1
90
Eczema
0
1.1
90
0
1.1
90
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98483
21354
Rat
RGD:3817
24811
Dog
transporter 1, ATP binding cassette subfamily B member
VGNC:47105
474866
Horse
transporter 1, ATP binding cassette subfamily B member
VGNC:23871
100060845
Cow
transporter 1, ATP binding cassette subfamily B member
VGNC:35598
524959
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transporter 1, ATP binding cassette subfamily B member
Horse
transporter 1, ATP binding cassette subfamily B member
Cow
transporter 1, ATP binding cassette subfamily B member
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03518-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (117)
1 – 10 of 117
TAP2
Tbio
Novelty:  0.0390555
p_int:  0.999999985
p_ni:  1.2e-8
p_wrong:  3e-9
Score:  0.963
Data Source:  BioPlex,Reactome,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.999994811
p_ni:  0.000005189
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.98757031
p_ni:  0.011602299
p_wrong:  0.000827391
Data Source:  BioPlex
TAPBP
Tbio
Novelty:  0.00328098
Score:  0.986
Data Source:  Reactome,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
Score:  0.985
Data Source:  STRINGDB
PSMB8
Tclin
Family:  Enzyme
Novelty:  0.00189046
Score:  0.97
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.969
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.96
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.96
Data Source:  STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
Score:  0.96
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.26

PubMed score by year
PubTator Score  520.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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