Tbio TAP1 Antigen peptide transporter 1

Protein Summary

Description

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q03518
• Q16149
• Q96CP4
• APT1

Gene Name

• TAP1

Ensembl ID

• ENST00000354258
• ENSP00000346206
• ENSG00000168394
• ENST00000383235
• ENSP00000372722
• ENSG00000206297
• ENST00000414467
• ENSP00000405356
• ENSG00000226173
• ENST00000418205
• ENSP00000401149
• ENSG00000227816
• ENST00000424897
• ENSP00000413080
• ENSG00000230705
• ENST00000439781
• ENSP00000415660
• ENSG00000224212
• ENST00000440894
• ENSP00000402316
• ENSG00000232367

Symbol

• ABCB2
• PSF1
• RING4
• Y3
• APT1
• PSF1
• ABC17
• ABCB2
• PSF-1
• RING4
• TAP1N
• D6S114E
• TAP1*0102N

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
virus perturbation	1
transcription factor perturbation	0.94
protein domain	0.92
biological term	0.9

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Antigen Peptide Transporter 1

Protein / ... / Cysteine Protease / Antigen Peptide Transporter 1

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcb Subfamily / Antigen Peptide Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: < 5)

Gene RIFs: 153   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: >= 5)

Gene RIFs: 153   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0