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Tbio
ERCC6
DNA excision repair protein ERCC-6

Protein Summary
Description
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355832
  • ENSP00000348089
  • ENSG00000225830

Symbol
  • CSB
  • CSB
  • CKN2
  • COFS
  • ARMD5
  • COFS1
  • POF11
  • RAD26
  • UVSS1
  • CSB-PGBD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.7   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.7   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
ERCC5
Tchem
Family:  Enzyme
Novelty:  0.00819696
Score:  0.98
Data Source:  STRINGDB
ERCC8
Tbio
Novelty:  0.02679635
Score:  0.933
Data Source:  Reactome,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.92
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.914
Data Source:  STRINGDB
XPA
Tchem
Novelty:  0.00137698
Score:  0.899
Data Source:  STRINGDB
ERCC4
Tbio
Family:  Enzyme
Novelty:  0.01076913
Score:  0.893
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.892
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.883
Data Source:  STRINGDB
XPC
Tbio
Novelty:  0.00775175
Score:  0.826
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.821
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
DNA Repair
Dual incision in TC-NER
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 6, chromatin remodeling factor
VGNC:51976
101058892
Macaque
ERCC excision repair 6, chromatin remodeling factor
710153
Mouse
MGI:1100494
319955
Rat
RGD:1311509
306274
Dog
ERCC excision repair 6, chromatin remodeling factor
VGNC:40445
477747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 6, chromatin remodeling factor
Macaque
ERCC excision repair 6, chromatin remodeling factor
Mouse
Rat
Dog
ERCC excision repair 6, chromatin remodeling factor
Publication Statistics
PubMed Score 132.70
PubMed score by year
PubTator Score 203.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title