Tclin PTH1R Parathyroid hormone/parathyroid hormone-related peptide receptor

Protein Summary

Description

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q03431
• Q2M1U3

Gene Name

• PTH1R

Ensembl ID

• ENST00000313049
• ENSP00000321999
• ENSG00000160801
• ENST00000418619
• ENSP00000411424
• ENST00000430002
• ENSP00000413774
• ENST00000449590
• ENSP00000402723

Symbol

• PTHR
• PTHR1
• PFE
• EKNS
• PTHR
• PTHR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.96
gene perturbation	0.87
PubMedID	0.8
transcription factor	0.78
phenotype	0.76

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Parathyroid Hormone Receptor / Parathyroid Hormone/parathyroid Hormone-related Peptide Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.32   (req: < 5)

Gene RIFs: 136   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.32   (req: >= 5)

Gene RIFs: 136   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3