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Tclin
PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

Protein Summary
Description
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313049
  • ENSP00000321999
  • ENSG00000160801
  • ENST00000418619
  • ENSP00000411424
  • ENST00000430002
  • ENSP00000413774
  • ENST00000449590
  • ENSP00000402723

Symbol
  • PTHR
  • PTHR1
  • PFE
  • EKNS
  • PTHR
  • PTHR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.96
gene perturbation
0.87
PubMedID
0.8
transcription factor
0.78
phenotype
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.09   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.09   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
2
4
47.7
C-reactive protein measurement
1
1
1
29.8
macrophage inflammatory protein 1b measurement
1
1
1
24.8
2
1
1
1.3
23
parental genotype effect measurement
1
1
1
22.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
4
47.7
C-reactive protein measurement
1
29.8
macrophage inflammatory protein 1b measurement
1
24.8
1
1.3
23
parental genotype effect measurement
1
22.2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (201)
1 – 10 of 201
DNAJC17
Tbio
Novelty: 0.42044015
p_int: 0.999996932
p_ni: 0.000003044
p_wrong: 2.3e-8
Score: 0.334
Data Source: BioPlex,STRINGDB
SIDT2
Tbio
Novelty: 0.07560652
p_int: 0.999424469
p_ni: 0.00057532
p_wrong: 2.12e-7
Data Source: BioPlex
SLC44A1
Tbio
Family: Transporter
Novelty: 0.01499456
p_int: 0.999412085
p_ni: 0.000360762
p_wrong: 0.000227153
Score: 0.183
Data Source: BioPlex,STRINGDB
SLC47A1
Tchem
Family: Transporter
Novelty: 0.00535064
p_int: 0.995070058
p_ni: 0.00440582
p_wrong: 0.000524122
Data Source: BioPlex
SLC12A9
Tdark
Family: Transporter
Novelty: 0.12936696
p_int: 0.994647764
p_ni: 0.005352236
Data Source: BioPlex
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
p_int: 0.993737923
p_ni: 0.006262077
Data Source: BioPlex
FADS1
Tchem
Family: Enzyme
Novelty: 0.00160193
p_int: 0.982677581
p_ni: 0.017321354
p_wrong: 0.000001065
Data Source: BioPlex
ATP13A2
Tbio
Family: Transporter
Novelty: 0.00623191
p_int: 0.975995722
p_ni: 0.024004271
p_wrong: 7e-9
Data Source: BioPlex
EVI5L
Tbio
Novelty: 0.70769557
p_int: 0.97189232
p_ni: 0.028067889
p_wrong: 0.000039791
Score: 0.158
Data Source: BioPlex,STRINGDB
CCPG1
Tbio
Novelty: 0.07685013
p_int: 0.963768892
p_ni: 0.036231108
Data Source: BioPlex
Publication Statistics
PubMed Score  218.09

PubMed score by year
PubTator Score  325.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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