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Tchem
PLAUR
Urokinase plasminogen activator surface receptor

Protein Summary
Description
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221264
  • ENSP00000221264
  • ENSG00000011422
  • ENST00000339082
  • ENSP00000342049
  • ENST00000340093
  • ENSP00000339328

Symbol
  • MO3
  • UPAR
  • CD87
  • UPAR
  • URKR
  • U-PAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
PubMedID
0.98
kinase perturbation
0.93
biological process
0.91
transcription factor perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1578.27   (req: < 5)
Gene RIFs: 550   (req: <= 3)
Antibodies: 538   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1578.27   (req: >= 5)
Gene RIFs: 550   (req: > 3)
Antibodies: 538   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0