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Tchem
PLAUR
Urokinase plasminogen activator surface receptor

Protein Summary
Description
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221264
  • ENSP00000221264
  • ENSG00000011422
  • ENST00000339082
  • ENSP00000342049
  • ENST00000340093
  • ENSP00000339328

Symbol
  • MO3
  • UPAR
  • CD87
  • UPAR
  • URKR
  • U-PAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
PubMedID
0.98
kinase perturbation
0.93
biological process
0.91
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1276.12   (req: < 5)
Gene RIFs: 474   (req: <= 3)
Antibodies: 538   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1276.12   (req: >= 5)
Gene RIFs: 474   (req: > 3)
Antibodies: 538   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
1
3
87.9
myeloid white cell count
2
1
2
87.9
TNF-related apoptosis-inducing ligand measurement
1
1
1
87.6
leukocyte count
2
1
2
87.6
sum of basophil and neutrophil counts
1
1
1
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
87.9
myeloid white cell count
2
87.9
TNF-related apoptosis-inducing ligand measurement
1
87.6
leukocyte count
2
87.6
sum of basophil and neutrophil counts
1
86
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, urokinase receptor
450103
Macaque
plasminogen activator, urokinase receptor
710662
Mouse
MGI:97612
18793
Rat
RGD:620597
50692
Horse
plasminogen activator, urokinase receptor
VGNC:21531
100033904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plasminogen activator, urokinase receptor
Macaque
plasminogen activator, urokinase receptor
Mouse
Rat
Horse
plasminogen activator, urokinase receptor
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03405-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Dissolution of Fibrin Clot
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (312)
1 – 10 of 312
LARGE1
Tbio
Family:  Enzyme
Novelty:  0.02518701
p_int:  0.999981552
p_ni:  0.000018444
p_wrong:  4e-9
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.999708736
p_ni:  0.000291264
Data Source:  BioPlex
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.999451607
p_ni:  0.000546592
p_wrong:  0.000001801
Score:  0.271
Data Source:  BioPlex,STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
p_int:  0.999391353
p_ni:  0.000608548
p_wrong:  9.8e-8
Score:  0.202
Data Source:  BioPlex,STRINGDB
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
p_int:  0.999125349
p_ni:  0.000874651
Data Source:  BioPlex
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.998902971
p_ni:  0.001097021
p_wrong:  8e-9
Data Source:  BioPlex
TATDN2
Tdark
Family:  Enzyme
Novelty:  1.40236433
p_int:  0.998535796
p_ni:  0.001143732
p_wrong:  0.000320472
Score:  0.161
Data Source:  BioPlex,STRINGDB
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
p_int:  0.998137639
p_ni:  0.001862361
Data Source:  BioPlex
LARGE2
Tbio
Family:  Enzyme
Novelty:  0.11843777
p_int:  0.995929991
p_ni:  0.004070009
Score:  0.224
Data Source:  BioPlex,STRINGDB
CHSY3
Tdark
Family:  Enzyme
Novelty:  0.17103933
p_int:  0.995070045
p_ni:  0.004929918
p_wrong:  3.7e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  1276.12

PubMed score by year
PubTator Score  1100.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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