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Tbio
PTS
6-pyruvoyl tetrahydrobiopterin synthase

Protein Summary
Description
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280362
  • ENSP00000280362
  • ENSG00000150787

Symbol
  • PTPS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
kinase perturbation
0.81
gene perturbation
0.68
transcription factor perturbation
0.68
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.24   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.24   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.999882792
p_ni:  0.000117208
Data Source:  BioPlex
TEX29
Tdark
Novelty:  2.30568043
p_int:  0.999803645
p_ni:  0.000010815
p_wrong:  0.00018554
Score:  0.228
Data Source:  BioPlex,STRINGDB
SYP
Tbio
Novelty:  0.00021543
p_int:  0.999790986
p_ni:  0.000003907
p_wrong:  0.000205106
Score:  0.203
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.998928721
p_ni:  0.000140876
p_wrong:  0.000930403
Data Source:  BioPlex
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.995056081
p_ni:  0.00466857
p_wrong:  0.000275349
Data Source:  BioPlex
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.945439936
p_ni:  0.053448819
p_wrong:  0.001111245
Data Source:  BioPlex
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.824676644
p_ni:  0.150117541
p_wrong:  0.025205815
Data Source:  BioPlex
SPR
Tchem
Family:  Enzyme
Novelty:  0.02144934
Score:  0.989
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.986
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.94
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
4
4
98.8
heel bone mineral density
2
3
3
88.4
blood protein measurement
1
1
1
80.8
interleukin 1 receptor antagonist measurement
1
1
1
80.5
interleukin-1 beta measurement
1
1
1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
4
98.8
heel bone mineral density
3
88.4
blood protein measurement
1
80.8
interleukin 1 receptor antagonist measurement
1
80.5
interleukin-1 beta measurement
1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
6-pyruvoyltetrahydropterin synthase
VGNC:3064
739126
Macaque
6-pyruvoyltetrahydropterin synthase
711642
Mouse
MGI:1338783
19286
Rat
RGD:68367
29498
Dog
6-pyruvoyltetrahydropterin synthase
VGNC:45203
611326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
6-pyruvoyltetrahydropterin synthase
Macaque
6-pyruvoyltetrahydropterin synthase
Mouse
Rat
Dog
6-pyruvoyltetrahydropterin synthase
Publication Statistics
PubMed Score 272.24
PubMed score by year
PubTator Score 191.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title