You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LMNB2
Lamin-B2

Protein Summary
Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325327
  • ENSP00000327054
  • ENSG00000176619

Symbol
  • LMN2
  • EPM9
  • LMN2
  • LAMB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
kinase perturbation
0.91
transcription factor perturbation
0.84
co-expressed gene
0.72
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.08   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.08   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (151)
1 – 10 of 151
FNTB
Tchem
Family: Enzyme
Novelty: 0.13625417
p_int: 0.961742586
p_ni: 0.038257414
Score: 0.337
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.07934297
p_int: 0.925445083
p_ni: 0.074554917
Data Source: BioPlex
ENTHD1
Tdark
p_int: 0.797916358
p_ni: 0.202083642
Data Source: BioPlex
TACR3
Tchem
Family: GPCR
Novelty: 0.00322406
p_int: 0.785911221
p_ni: 0.214088779
Data Source: BioPlex
LMNA
Tbio
Novelty: 0.00051948
Score: 0.957
Data Source: STRINGDB
CASP6
Tchem
Family: Enzyme
Novelty: 0.00311641
Score: 0.95
Data Source: STRINGDB
LMNB1
Tbio
Novelty: 0.00131872
Score: 0.949
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.0001911
Score: 0.925
Data Source: STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00224248
Score: 0.923
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00046573
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  415.08

PubMed score by year
PubTator Score  74.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer