CENPC
Centromere protein C
Protein Summary
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
- ENST00000273853
- ENSP00000273853
- ENSG00000145241
- ENST00000506882
- ENSP00000426078
- CENPC1
- ICEN7
- MIF2
- hcp-4
- CENP-C
- CENPC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
histone modification site profile | 0.71 | ||
tissue sample | 0.64 | ||
cellular component | 0.63 | ||
transcription factor | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.1 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 213 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.1 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 213 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (173)
RBM34
Novelty: 0.58131282
p_int: 0.999439341
p_ni: 0.000560652
p_wrong: 7e-9
Score: 0.268
Data Source: BioPlex,STRINGDB
MIS12
Novelty: 0.05345698
p_int: 0.998889356
p_ni: 0.001018154
p_wrong: 0.00009249
Score: 0.999
Data Source: BioPlex,STRINGDB
DSN1
Novelty: 0.05336903
p_int: 0.99874813
p_ni: 0.00125187
Score: 0.996
Data Source: BioPlex,STRINGDB
DGCR8
Novelty: 0.00271221
p_int: 0.995221834
p_ni: 0.004778163
p_wrong: 3e-9
Data Source: BioPlex
RBM4
Novelty: 0.02034191
p_int: 0.993813045
p_ni: 0.006186931
p_wrong: 2.3e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
H2AFY2
Novelty: 0.09948698
p_int: 0.992095818
p_ni: 0.007125218
p_wrong: 0.000778964
Data Source: BioPlex
CENPU
Novelty: 0.03681625
p_int: 0.989745057
p_ni: 0.010018295
p_wrong: 0.000236648
Score: 0.992
Data Source: BioPlex,STRINGDB
NDC80
Novelty: 0.00331814
p_int: 0.988946093
p_ni: 0.011053906
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
NIFK
Novelty: 0.01221562
p_int: 0.9868539
p_ni: 0.012785562
p_wrong: 0.000360537
Score: 0.211
Data Source: BioPlex,STRINGDB
RPL18
Novelty: 0.01765545
p_int: 0.981340971
p_ni: 0.017677281
p_wrong: 0.000981748
Data Source: BioPlex
Nearest Tclin Targets
Pathways (19)
Reactome (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (2)
Components (12)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | centromere protein C | VGNC:2026 | 461295 | |||||
Macaque | centromere protein C | 710620 | ||||||
Mouse | MGI:99700 | 12617 | ||||||
Rat | RGD:1303061 | 305270 | ||||||
Dog | centromere protein C | VGNC:39102 | 475158 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | centromere protein C | |||||
Macaque | centromere protein C | |||||
Mouse | ||||||
Rat | ||||||
Dog | centromere protein C | |||||
Publication Statistics
PubMed Score 153.10
PubMed score by year
PubTator Score 132.62
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (26)
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