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Tbio
CENPC
Centromere protein C

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273853
  • ENSP00000273853
  • ENSG00000145241
  • ENST00000506882
  • ENSP00000426078

Symbol
  • CENPC1
  • ICEN7
  • MIF2
  • hcp-4
  • CENP-C
  • CENPC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.71
tissue sample
0.64
cellular component
0.63
transcription factor
0.63


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein C
VGNC:2026
461295
Macaque
centromere protein C
710620
Mouse
MGI:99700
12617
Rat
RGD:1303061
305270
Dog
centromere protein C
VGNC:39102
475158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein C
Macaque
centromere protein C
Mouse
Rat
Dog
centromere protein C
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03188-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (173)
1 – 10 of 173
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.999439341
p_ni: 0.000560652
p_wrong: 7e-9
Score: 0.268
Data Source: BioPlex,STRINGDB
MIS12
Tbio
Novelty: 0.05345698
p_int: 0.998889356
p_ni: 0.001018154
p_wrong: 0.00009249
Score: 0.999
Data Source: BioPlex,STRINGDB
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.99874813
p_ni: 0.00125187
Score: 0.996
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.995221834
p_ni: 0.004778163
p_wrong: 3e-9
Data Source: BioPlex
RBM4
Tbio
Novelty: 0.02034191
p_int: 0.993813045
p_ni: 0.006186931
p_wrong: 2.3e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.992095818
p_ni: 0.007125218
p_wrong: 0.000778964
Data Source: BioPlex
CENPU
Tbio
Novelty: 0.03681625
p_int: 0.989745057
p_ni: 0.010018295
p_wrong: 0.000236648
Score: 0.992
Data Source: BioPlex,STRINGDB
NDC80
Tbio
Novelty: 0.00331814
p_int: 0.988946093
p_ni: 0.011053906
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
NIFK
Tbio
Novelty: 0.01221562
p_int: 0.9868539
p_ni: 0.012785562
p_wrong: 0.000360537
Score: 0.211
Data Source: BioPlex,STRINGDB
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.981340971
p_ni: 0.017677281
p_wrong: 0.000981748
Data Source: BioPlex
Publication Statistics
PubMed Score  152.00

PubMed score by year
PubTator Score  132.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer