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Tchem
PPARD
Peroxisome proliferator-activated receptor delta

Protein Classes
Protein Summary
Description
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Kno ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311565
  • ENSP00000310928
  • ENSG00000112033
  • ENST00000337400
  • ENSP00000337063
  • ENST00000360694
  • ENSP00000353916
  • ENST00000418635
  • ENSP00000413314
  • ENST00000448077
  • ENSP00000414372

Symbol
  • NR1C2
  • PPARB
  • FAAR
  • NUC1
  • NUCI
  • NR1C2
  • NUCII
  • PPARB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
biological term
0.98
protein domain
0.92
transcription factor binding site profile
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.87   (req: < 5)
Gene RIFs: 234   (req: <= 3)
Antibodies: 572   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.87   (req: >= 5)
Gene RIFs: 234   (req: > 3)
Antibodies: 572   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 359
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tretinoin
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
90.4
body height
4
3
3
6.8
76.2
platelet count
1
1
1
42.4
lymphocyte count
1
1
1
35.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
90.4
body height
3
6.8
76.2
platelet count
1
42.4
lymphocyte count
1
35.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor delta
VGNC:7904
463188
Macaque
peroxisome proliferator activated receptor delta
718861
Mouse
MGI:101884
19015
Rat
RGD:3370
25682
Dog
peroxisome proliferator activated receptor delta
VGNC:44835
481756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxisome proliferator activated receptor delta
Macaque
peroxisome proliferator activated receptor delta
Mouse
Rat
Dog
peroxisome proliferator activated receptor delta
Protein Structure (42 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03181-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 42
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (111)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Gene expression (Transcription)
Generic Transcription Pathway
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Gene Ontology Terms (83)
Items per page:
10
1 – 10 of 20
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (101)
1 – 10 of 101
MDM4
Tchem
Novelty: 0.00321558
p_int: 0.999974694
p_ni: 0.000025194
p_wrong: 1.12e-7
Score: 0.755
Data Source: BioPlex,STRINGDB
RNF31
Tbio
Family: Enzyme
Novelty: 0.01394304
p_int: 0.994905939
p_ni: 0.005094036
p_wrong: 2.5e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
TRMT6
Tbio
Family: Enzyme
Novelty: 0.06718902
p_int: 0.994272102
p_ni: 0.005727898
Score: 0.228
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.954846374
p_ni: 0.045153626
Score: 0.323
Data Source: BioPlex,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
p_int: 0.953782302
p_ni: 0.046217658
p_wrong: 4e-8
Score: 0.698
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.751495965
p_ni: 0.248504035
Data Source: BioPlex
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.965
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.955
Data Source: Reactome,STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
Score: 0.948
Data Source: STRINGDB
FABP5
Tchem
Novelty: 0.00570755
Score: 0.948
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  296.87

PubMed score by year
PubTator Score  612.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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