You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TGFBR3
Transforming growth factor beta receptor type 3

Protein Summary
Description
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000212355
  • ENSP00000212355
  • ENSG00000069702
  • ENST00000370399
  • ENSP00000359426
  • ENST00000465892
  • ENSP00000432638
  • ENST00000525962
  • ENSP00000436127

Symbol
  • BGCAN
  • betaglycan
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
molecular function
0.99
biological process
0.98
disease
0.87
gene perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.15   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.15   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0