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Tbio
TGFBR3
Transforming growth factor beta receptor type 3

Protein Summary
Description
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000212355
  • ENSP00000212355
  • ENSG00000069702
  • ENST00000370399
  • ENSP00000359426
  • ENST00000465892
  • ENSP00000432638
  • ENST00000525962
  • ENSP00000436127

Symbol
  • BGCAN
  • betaglycan
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
molecular function
0.99
biological process
0.98
disease
0.87
gene perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.75   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.75   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
82.6
1
1
0
1.1
62.1
QT interval
1
1
0
9.3
36.3
response to tetracyclic antidepressant
1
1
0
9.3
36.3
response to tricyclic antidepressant
1
1
0
9.3
36.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
82.6
0
1.1
62.1
QT interval
0
9.3
36.3
response to tetracyclic antidepressant
0
9.3
36.3
response to tricyclic antidepressant
0
9.3
36.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 3
VGNC:10422
457016
Macaque
transforming growth factor beta receptor 3
705053
Mouse
MGI:104637
21814
Rat
RGD:61821
29610
Dog
transforming growth factor beta receptor 3
VGNC:54077
490163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor 3
Macaque
transforming growth factor beta receptor 3
Mouse
Rat
Dog
transforming growth factor beta receptor 3
Pathways (72)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TGF_beta_Receptor
PathwayCommons: pid
TGF-beta receptor signaling
Name
Explore in Pharos
Explore in Source
TGF_beta_Receptor
TGF-beta receptor signaling
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (93)
1 – 10 of 93
HADHA
Tbio
Novelty: 0.00385746
p_int: 0.999997483
p_ni: 0.000002517
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.999883983
p_ni: 0.000116017
Data Source: BioPlex
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999550516
p_ni: 0.000449481
p_wrong: 3e-9
Data Source: BioPlex
FGF1
Tchem
Novelty: 0.00055979
p_int: 0.99907326
p_ni: 0.000926737
p_wrong: 4e-9
Score: 0.26
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.999013995
p_ni: 0.000986004
p_wrong: 1e-9
Data Source: BioPlex
ATP1B4
Tdark
Family: Transporter
Novelty: 0.08212894
p_int: 0.998818045
p_ni: 0.00118194
p_wrong: 1.5e-8
Data Source: BioPlex
KLK11
Tbio
Family: Enzyme
Novelty: 0.00267977
p_int: 0.998425026
p_ni: 0.001574241
p_wrong: 7.32e-7
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.998194983
p_ni: 0.001796844
p_wrong: 0.000008173
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.998178056
p_ni: 0.001818687
p_wrong: 0.000003257
Data Source: BioPlex
LRRTM4
Tbio
Novelty: 0.07741851
p_int: 0.998138098
p_ni: 0.001861897
p_wrong: 5e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  128.75

PubMed score by year
PubTator Score  110.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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