You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KMT2A
Histone-lysine N-methyltransferase 2A

Protein Summary
Description
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389506
  • ENSP00000374157
  • ENSG00000118058
  • ENST00000534358
  • ENSP00000436786
  • ENST00000649699
  • ENSP00000496927

Symbol
  • ALL1
  • CXXC7
  • HRX
  • HTRX
  • MLL
  • MLL1
  • TRX1
  • HRX
  • MLL
  • MLL1
  • TRX1
  • ALL-1
  • CXXC7
  • HTRX1
  • MLL1A
  • WDSTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
molecular function
0.99
biological process
0.96
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 730.04   (req: < 5)
Gene RIFs: 358   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 730.04   (req: >= 5)
Gene RIFs: 358   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0