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Tbio
ACY1
Aminoacylase-1

Protein Summary
Description
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404366
  • ENSP00000384296
  • ENSG00000243989
  • ENST00000476351
  • ENSP00000417056
  • ENST00000476854
  • ENSP00000419262
  • ENST00000494103
  • ENSP00000417618
  • ENST00000636358
  • ENSP00000490149

Symbol
  • ACY-1
  • ACY1D
  • HEL-S-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
histone modification site profile
0.79
transcription factor binding site profile
0.67
disease
0.64
PubMedID
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.13   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.13   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03154-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Defective ACY1 causes encephalopathy
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Defective ACY1 causes encephalopathy
Disease
Diseases of metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
TRIM33
Tbio
Family: Epigenetic
Novelty: 0.00415877
p_int: 0.999298204
p_ni: 0.000701796
Score: 0.206
Data Source: BioPlex,STRINGDB
PPME1
Tchem
Family: Enzyme
Novelty: 0.01559862
p_int: 0.990841389
p_ni: 0.009158611
Score: 0.217
Data Source: BioPlex,STRINGDB
NUDT1
Tchem
Family: Enzyme
Novelty: 0.00383386
p_int: 0.985750564
p_ni: 0.013997734
p_wrong: 0.000251703
Score: 0.799
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.958018439
p_ni: 0.041981561
Score: 0.179
Data Source: BioPlex,STRINGDB
PECR
Tbio
Family: Enzyme
Novelty: 0.01550165
p_int: 0.928388137
p_ni: 0.071611863
Score: 0.313
Data Source: BioPlex,STRINGDB
PHOSPHO1
Tchem
Family: Enzyme
Novelty: 0.05458897
p_int: 0.907177698
p_ni: 0.092822302
Score: 0.418
Data Source: BioPlex,STRINGDB
BOLL
Tbio
Novelty: 0.02333312
p_int: 0.902165021
p_ni: 0.097834979
Score: 0.29
Data Source: BioPlex,STRINGDB
OTC
Tchem
Family: Enzyme
Novelty: 0.00544004
Score: 0.947
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.935
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.13

PubMed score by year
PubTator Score  123.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer