Tbio CAV1 Caveolin-1

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q03135
• Q9UGP1
• Q9UNG1
• Q9UQH6

Gene Name

• CAV1

Ensembl ID

• ENST00000341049
• ENSP00000339191
• ENSG00000105974
• ENST00000393467
• ENSP00000377110
• ENST00000393468
• ENSP00000377111
• ENST00000405348
• ENSP00000384348
• ENST00000614113
• ENSP00000479447

Symbol

• CAV
• CGL3
• PPH3
• BSCL3
• LCCNS
• VIP21
• MSTP085

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
hub protein	1
gene perturbation	0.99
PubMedID	0.99

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.68   (req: < 5)

Gene RIFs: 726   (req: <= 3)

Antibodies: 1107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.68   (req: >= 5)

Gene RIFs: 726   (req: > 3)

Antibodies: 1107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (437)

Explore Interacting Targets

1 – 10 of 437

• See Interactions on String-DB

CC2D1A

Tbio

Novelty:  0.01970021

p_int:  0.999999818

p_ni:  1.82e-7

Data Source:  BioPlex

YIPF3

Tbio

Novelty:  0.12021667

p_int:  0.999975774

p_ni:  0.000024226

Data Source:  BioPlex

SMPD3

Tchem

Family:  Enzyme

Novelty:  0.01053328

p_int:  0.999964587

p_ni:  0.000032627

p_wrong:  0.000002786

Score:  0.272

Data Source:  BioPlex,STRINGDB

SLC22A9

Tbio

Family:  Transporter

Novelty:  0.02212992

p_int:  0.999944682

p_ni:  0.000055318

Score:  0.217

Data Source:  BioPlex,STRINGDB

CAV3

Tbio

Novelty:  0.00190092

p_int:  0.999885841

p_ni:  0.000113977

p_wrong:  1.83e-7

Score:  0.825

Data Source:  BioPlex,STRINGDB

MSRB2

Tbio

Family:  Enzyme

Novelty:  0.00729088

p_int:  0.999885527

p_ni:  0.000114061

p_wrong:  4.12e-7

Data Source:  BioPlex

TACR1

Tclin

Family:  GPCR

Novelty:  0.00062762

p_int:  0.99960269

p_ni:  0.00039731

p_wrong:  1e-9

Score:  0.174

Data Source:  BioPlex,STRINGDB

FAF2

Tbio

Novelty:  0.03048598

p_int:  0.99960071

p_ni:  0.000381592

p_wrong:  0.000017698

Data Source:  BioPlex

P2RY12

Tclin

Family:  GPCR

Novelty:  0.00035406

p_int:  0.99946444

p_ni:  0.000527683

p_wrong:  0.000007877

Data Source:  BioPlex

HK1

Tchem

Family:  Kinase

Novelty:  0.00195554

p_int:  0.99583932

p_ni:  0.002136622

p_wrong:  0.002024058

Score:  0.277

Data Source:  BioPlex,STRINGDB

Pathways (58)

Reactome (26)

KEGG (6)

PathwayCommons (16)

WikiPathways (10)

Basigin interactions (R-HSA-210991)

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1 – 5 of 26

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Basigin interactions	25 targets	R-HSA-210991
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391

Name	Explore in Pharos	Explore in Source
Basigin interactions	25 targets	R-HSA-210991
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
ESR-mediated signaling	189 targets	R-HSA-8939211
Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391

Gene Ontology Terms (136)

Functions (16)

Components (22)

Processes (98)

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10

1 – 10 of 16

GO Term	Evidence	Assigned by
inward rectifier potassium channel inhibitor activity	Inferred from Direct Assay (IDA)	BHF-UCL
structural molecule activity	Inferred from Direct Assay (IDA)	UniProtKB
ATPase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
nitric-oxide synthase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein kinase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
Rac GTPase binding	Inferred from Physical Interaction (IPI)	AgBase
signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

GWAS Traits (21)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	8	6	0	1.1	98
intraocular pressure measurement	EFO_0004695	8	5	11		97.5
glaucoma	EFO_0000516	3	3	0	1.1	93.2
electrocardiography	EFO_0004327	2	2	12	6.4	92.1
PR interval	EFO_0004462	7	3	0	2.2	92.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	0	1.1	98
intraocular pressure measurement	EFO_0004695	11		97.5
glaucoma	EFO_0000516	0	1.1	93.2
electrocardiography	EFO_0004327	12	6.4	92.1
PR interval	EFO_0004462	0	2.2	92.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative initiation
Cell membrane
Complete proteome
Congenital generalized lipodystrophy
Diabetes mellitus
Direct protein sequencing
Disease mutation
Golgi apparatus
Host-virus interaction

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
electrocardiography
glaucoma
heart rate
heart rate response to exercise
heart rate response to recovery post exercise
intraocular pressure measurement
lymphocyte count
lymphocyte percentage of leukocytes
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	caveolin 1	VGNC:4295	463670
Macaque	caveolin 1		704449
Mouse	caveolin 1, caveolae protein	MGI:102709	12389
Rat	caveolin 1	RGD:2280	25404
Dog	caveolin 1	VGNC:38751	403980

Species	Name	OMA	EggNOG	Inparanoid
Chimp	caveolin 1
Macaque	caveolin 1
Mouse	caveolin 1, caveolae protein
Rat	caveolin 1
Dog	caveolin 1

Publication Statistics

PubMed Score 3372.68

PubMed score by year

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PubTator Score 2703.47

PubTator score by year

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