Tbio CAV1 Caveolin-1

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Caveolin-1

Protein / Structural Protein / Caveolin-1

Protein / Membrane Traffic Protein / Caveolin-1

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-1

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q03135
• Q9UGP1
• Q9UNG1
• Q9UQH6

Gene Name

• CAV1

Ensembl ID

• ENST00000341049
• ENSP00000339191
• ENSG00000105974
• ENST00000393467
• ENSP00000377110
• ENST00000393468
• ENSP00000377111
• ENST00000405348
• ENSP00000384348
• ENST00000614113
• ENSP00000479447

Symbol

• CAV
• CGL3
• PPH3
• BSCL3
• LCCNS
• VIP21
• MSTP085

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
hub protein	1
gene perturbation	0.99
PubMedID	0.99

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2596.52   (req: < 5)

Gene RIFs: 726   (req: <= 3)

Antibodies: 1107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2596.52   (req: >= 5)

Gene RIFs: 726   (req: > 3)

Antibodies: 1107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (58)

Reactome (26)

KEGG (6)

PathwayCommons (16)

WikiPathways (10)

Basigin interactions (R-HSA-210991)

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Items per page:

5

1 – 5 of 26

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Basigin interactions	25 targets	R-HSA-210991
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391

Name	Explore in Pharos	Explore in Source
Basigin interactions	25 targets	R-HSA-210991
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
ESR-mediated signaling	189 targets	R-HSA-8939211
Extra-nuclear estrogen signaling	74 targets	R-HSA-9009391

Gene Ontology Terms (136)

Functions (16)

Components (22)

Processes (98)

Items per page:

10

1 – 10 of 16

GO Term	Evidence	Assigned by
inward rectifier potassium channel inhibitor activity	Inferred from Direct Assay (IDA)	BHF-UCL
structural molecule activity	Inferred from Direct Assay (IDA)	UniProtKB
ATPase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ion channel binding	Inferred from Physical Interaction (IPI)	BHF-UCL
nitric-oxide synthase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein kinase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
Rac GTPase binding	Inferred from Physical Interaction (IPI)	AgBase
signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Protein-Protein Interactions (437)

Explore Interacting Targets

1 – 10 of 437

• See Interactions on String-DB

CC2D1A

Tbio

Novelty: 0.01893881

p_int: 0.999999818

p_ni: 1.82e-7

Data Source: BioPlex

YIPF3

Tbio

Novelty: 0.03141831

p_int: 0.999975774

p_ni: 0.000024226

Data Source: BioPlex

SMPD3

Tbio

Family: Enzyme

Novelty: 0.01367455

p_int: 0.999964587

p_ni: 0.000032627

p_wrong: 0.000002786

Score: 0.272

Data Source: BioPlex,STRINGDB

SLC22A9

Tbio

Family: Transporter

Novelty: 0.02803169

p_int: 0.999944682

p_ni: 0.000055318

Score: 0.217

Data Source: BioPlex,STRINGDB

CAV3

Tbio

Novelty: 0.00250765

p_int: 0.999885841

p_ni: 0.000113977

p_wrong: 1.83e-7

Score: 0.825

Data Source: BioPlex,STRINGDB

MSRB2

Tbio

Family: Enzyme

Novelty: 0.01205613

p_int: 0.999885527

p_ni: 0.000114061

p_wrong: 4.12e-7

Data Source: BioPlex

TACR1

Tclin

Family: GPCR

Novelty: 0.00074286

p_int: 0.99960269

p_ni: 0.00039731

p_wrong: 1e-9

Score: 0.174

Data Source: BioPlex,STRINGDB

FAF2

Tbio

Novelty: 0.03242029

p_int: 0.99960071

p_ni: 0.000381592

p_wrong: 0.000017698

Data Source: BioPlex

P2RY12

Tclin

Family: GPCR

Novelty: 0.00057146

p_int: 0.99946444

p_ni: 0.000527683

p_wrong: 0.000007877

Data Source: BioPlex

HK1

Tchem

Family: Kinase

Novelty: 0.00089993

p_int: 0.99583932

p_ni: 0.002136622

p_wrong: 0.002024058

Score: 0.277

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  2596.52

PubMed score by year

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PubTator Score  2703.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFED

1-70

VIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIE

70-140

IQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI

140-178

MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI

Find similar targets by:

Uniprot Keyword

Acetylation
Alternative initiation
Cell membrane
Complete proteome
Congenital generalized lipodystrophy
Diabetes mellitus
Direct protein sequencing
Disease mutation
Golgi apparatus
Host-virus interaction