Tbio CAV1 Caveolin-1

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q03135
• Q9UGP1
• Q9UNG1
• Q9UQH6

Gene Name

• CAV1

Ensembl ID

• ENST00000341049
• ENSP00000339191
• ENSG00000105974
• ENST00000393467
• ENSP00000377110
• ENST00000393468
• ENSP00000377111
• ENST00000405348
• ENSP00000384348
• ENST00000614113
• ENSP00000479447

Symbol

• CAV
• CGL3
• PPH3
• BSCL3
• LCCNS
• VIP21
• MSTP085

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
hub protein	1
gene perturbation	0.99
PubMedID	0.99

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Caveolin-1

Protein / Structural Protein / Caveolin-1

Protein / Membrane Traffic Protein / Caveolin-1

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3630.25   (req: < 5)

Gene RIFs: 887   (req: <= 3)

Antibodies: 1107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3630.25   (req: >= 5)

Gene RIFs: 887   (req: > 3)

Antibodies: 1107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0