Protein Classes
Protein Summary
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to ...more
- ENST00000341049
- ENSP00000339191
- ENSG00000105974
- ENST00000393467
- ENSP00000377110
- ENST00000393468
- ENSP00000377111
- ENST00000405348
- ENSP00000384348
- ENST00000614113
- ENSP00000479447
- CAV
- CGL3
- PPH3
- BSCL3
- LCCNS
- VIP21
- MSTP085
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
hub protein | 1 | ||
gene perturbation | 0.99 | ||
PubMedID | 0.99 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3299.14 (req: < 5)
Gene RIFs: 726 (req: <= 3)
Antibodies: 1107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3299.14 (req: >= 5)
Gene RIFs: 726 (req: > 3)
Antibodies: 1107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 114
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 4 | 0 | 1.1 | 98.9 | |||||
PR interval | 7 | 2 | 0 | 2.2 | 97.4 | ||||
electrocardiography | 2 | 2 | 12 | 6.4 | 94.8 | ||||
lymphocyte count | 2 | 1 | 2 | 75.2 | |||||
QT interval | 1 | 1 | 0 | 6.4 | 72.1 | ||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 98.9 | |||||
PR interval | 0 | 2.2 | 97.4 | ||||
electrocardiography | 12 | 6.4 | 94.8 | ||||
lymphocyte count | 2 | 75.2 | |||||
QT interval | 0 | 6.4 | 72.1 | ||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | caveolin 1 | VGNC:4295 | 463670 | |||||
Macaque | caveolin 1 | 704449 | ||||||
Mouse | MGI:102709 | 12389 | ||||||
Rat | RGD:2280 | 25404 | ||||||
Dog | caveolin 1 | VGNC:38751 | 403980 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | caveolin 1 | |||||
Macaque | caveolin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | caveolin 1 | |||||
Pathways (58)
Reactome (26)
KEGG (6)
PathwayCommons (16)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 26
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Basigin interactions | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Reactome | ESR-mediated signaling | ||||
Reactome | Extra-nuclear estrogen signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Basigin interactions | ||||
Cell surface interactions at the vascular wall | ||||
Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
ESR-mediated signaling | ||||
Extra-nuclear estrogen signaling | ||||
Gene Ontology Terms (136)
Functions (16)
Components (22)
Processes (98)
Items per page:
10
1 – 10 of 16
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (437)
1 – 10 of 437
CC2D1A
Novelty: 0.01970021
p_int: 0.999999818
p_ni: 1.82e-7
Data Source: BioPlex
YIPF3
Novelty: 0.12021667
p_int: 0.999975774
p_ni: 0.000024226
Data Source: BioPlex
SMPD3
Family: Enzyme
Novelty: 0.01053328
p_int: 0.999964587
p_ni: 0.000032627
p_wrong: 0.000002786
Score: 0.272
Data Source: BioPlex,STRINGDB
SLC22A9
Family: Transporter
Novelty: 0.02212992
p_int: 0.999944682
p_ni: 0.000055318
Score: 0.217
Data Source: BioPlex,STRINGDB
CAV3
Novelty: 0.00190092
p_int: 0.999885841
p_ni: 0.000113977
p_wrong: 1.83e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
MSRB2
Family: Enzyme
Novelty: 0.00729088
p_int: 0.999885527
p_ni: 0.000114061
p_wrong: 4.12e-7
Data Source: BioPlex
TACR1
Family: GPCR
Novelty: 0.00062762
p_int: 0.99960269
p_ni: 0.00039731
p_wrong: 1e-9
Score: 0.174
Data Source: BioPlex,STRINGDB
FAF2
Novelty: 0.03048598
p_int: 0.99960071
p_ni: 0.000381592
p_wrong: 0.000017698
Data Source: BioPlex
P2RY12
Family: GPCR
Novelty: 0.00035406
p_int: 0.99946444
p_ni: 0.000527683
p_wrong: 0.000007877
Data Source: BioPlex
HK1
Family: Kinase
Novelty: 0.00195554
p_int: 0.99583932
p_ni: 0.002136622
p_wrong: 0.002024058
Score: 0.277
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 3299.14
PubMed score by year
PubTator Score 2703.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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