MECOM
MDS1 and EVI1 complex locus protein
Protein Summary
Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
- ENST00000264674
- ENSP00000264674
- ENSG00000085276
- ENST00000464456
- ENSP00000419770
- ENST00000468789
- ENSP00000419995
- ENST00000494292
- ENSP00000417899
- ENST00000628990
- ENSP00000486104
- EVI1
- MDS1
- EVI1
- MDS1
- KMT8E
- PRDM3
- RUSAT2
- MDS1-EVI1
- AML1-EVI-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.27 (req: < 5)
Gene RIFs: 117 (req: <= 3)
Antibodies: 400 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.27 (req: >= 5)
Gene RIFs: 117 (req: > 3)
Antibodies: 400 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (144)
CTBP1
Novelty: 0.00243818
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.948
Data Source: BioPlex,STRINGDB
SPDEF
Family: TF
Novelty: 0.00618802
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.267
Data Source: BioPlex,STRINGDB
ACTN3
Novelty: 0.00375035
p_int: 0.999998782
p_ni: 0.000001164
p_wrong: 5.4e-8
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (12)
Reactome (8)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Intracellular signaling by second messengers | ||||
Reactome | PIP3 activates AKT signaling | ||||
Reactome | PKMTs methylate histone lysines | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Intracellular signaling by second messengers | ||||
PIP3 activates AKT signaling | ||||
PKMTs methylate histone lysines | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (56)
Items per page:
1 – 5 of 56
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 5 | 5 | 95.1 | |||||
hematocrit | 3 | 3 | 3 | 92.9 | |||||
blood urea nitrogen measurement | 3 | 3 | 3 | 92 | |||||
mean platelet volume | 2 | 2 | 3 | 88.3 | |||||
hemoglobin measurement | 2 | 2 | 2 | 86.2 | |||||
Items per page:
1 – 5 of 56
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 5 | 95.1 | |||||
hematocrit | 3 | 92.9 | |||||
blood urea nitrogen measurement | 3 | 92 | |||||
mean platelet volume | 3 | 88.3 | |||||
hemoglobin measurement | 2 | 86.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MDS1 and EVI1 complex locus | VGNC:2041 | 460837 | |||||
Macaque | MDS1 and EVI1 complex locus | 698603 | ||||||
Mouse | MGI:95457 | 14013 | ||||||
Rat | RGD:1310997 | 294924 | ||||||
Dog | MDS1 and EVI1 complex locus | VGNC:43114 | 488148 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MDS1 and EVI1 complex locus | |||||
Macaque | MDS1 and EVI1 complex locus | |||||
Mouse | ||||||
Rat | ||||||
Dog | MDS1 and EVI1 complex locus | |||||
Publication Statistics
PubMed Score 247.27
PubMed score by year
PubTator Score 281.60
PubTator score by year
Related Publications
Text Mined References (148)
GeneRif Annotations (117)
Items per page:
0 of 0
PMID | Year | Title |
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