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Tbio
MECOM
MDS1 and EVI1 complex locus protein

Protein Summary
Description
Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264674
  • ENSP00000264674
  • ENSG00000085276
  • ENST00000464456
  • ENSP00000419770
  • ENST00000468789
  • ENSP00000419995
  • ENST00000494292
  • ENSP00000417899
  • ENST00000628990
  • ENSP00000486104

Symbol
  • EVI1
  • MDS1
  • EVI1
  • MDS1
  • KMT8E
  • PRDM3
  • RUSAT2
  • MDS1-EVI1
  • AML1-EVI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.42   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.42   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
3
3
3
89.6
hematocrit
3
3
3
88.6
BMI-adjusted waist-hip ratio
1
1
1
86.4
intraocular pressure measurement
4
3
5
85.5
mean platelet volume
2
2
3
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
3
89.6
hematocrit
3
88.6
BMI-adjusted waist-hip ratio
1
86.4
intraocular pressure measurement
5
85.5
mean platelet volume
3
84.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PKMTs methylate histone lysines
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
MYH2
Tbio
Novelty: 0.00365878
p_int: 0.999999999
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
MYH1
Tbio
Novelty: 0.00472973
p_int: 0.999999999
p_ni: 1e-9
Data Source: BioPlex
MYLPF
Tbio
Novelty: 0.00960325
p_int: 0.999999988
p_ni: 1.2e-8
Data Source: BioPlex
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.948
Data Source: BioPlex,STRINGDB
MYH7
Tbio
Novelty: 0.00268092
p_int: 0.999999973
p_ni: 2.7e-8
Data Source: BioPlex
MYH4
Tbio
Novelty: 0.00556982
p_int: 0.999999958
p_ni: 4.2e-8
Data Source: BioPlex
MYH8
Tbio
Novelty: 0.01020559
p_int: 0.999999957
p_ni: 4.3e-8
Data Source: BioPlex
CKM
Tbio
Family: Kinase
Novelty: 0.00239628
p_int: 0.999999952
p_ni: 4.8e-8
Data Source: BioPlex
SPDEF
Tbio
Family: TF
Novelty: 0.00618802
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.267
Data Source: BioPlex,STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
p_int: 0.999998782
p_ni: 0.000001164
p_wrong: 5.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  240.42

PubMed score by year
PubTator Score  281.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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