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Tbio
MECOM
MDS1 and EVI1 complex locus protein

Protein Summary
Description
Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264674
  • ENSP00000264674
  • ENSG00000085276
  • ENST00000464456
  • ENSP00000419770
  • ENST00000468789
  • ENSP00000419995
  • ENST00000494292
  • ENSP00000417899
  • ENST00000628990
  • ENSP00000486104

Symbol
  • EVI1
  • MDS1
  • EVI1
  • MDS1
  • KMT8E
  • PRDM3
  • RUSAT2
  • MDS1-EVI1
  • AML1-EVI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.27   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.27   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
MYH2
Tbio
Novelty:  0.00365878
p_int:  0.999999999
p_ni:  1e-9
p_wrong:  1e-9
Data Source:  BioPlex
MYH1
Tbio
Novelty:  0.00472973
p_int:  0.999999999
p_ni:  1e-9
Data Source:  BioPlex
MYLPF
Tbio
Novelty:  0.00960325
p_int:  0.999999988
p_ni:  1.2e-8
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.948
Data Source:  BioPlex,STRINGDB
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.999999973
p_ni:  2.7e-8
Data Source:  BioPlex
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999999958
p_ni:  4.2e-8
Data Source:  BioPlex
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.999999957
p_ni:  4.3e-8
Data Source:  BioPlex
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999999952
p_ni:  4.8e-8
Data Source:  BioPlex
SPDEF
Tbio
Family:  TF
Novelty:  0.00618802
p_int:  0.999999759
p_ni:  2.41e-7
Score:  0.267
Data Source:  BioPlex,STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.999998782
p_ni:  0.000001164
p_wrong:  5.4e-8
Data Source:  BioPlex
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

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1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
5
5
95.1
hematocrit
3
3
3
92.9
blood urea nitrogen measurement
3
3
3
92
mean platelet volume
2
2
3
88.3
hemoglobin measurement
2
2
2
86.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
5
95.1
hematocrit
3
92.9
blood urea nitrogen measurement
3
92
mean platelet volume
3
88.3
hemoglobin measurement
2
86.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MDS1 and EVI1 complex locus
VGNC:2041
460837
Macaque
MDS1 and EVI1 complex locus
698603
Mouse
MGI:95457
14013
Rat
RGD:1310997
294924
Dog
MDS1 and EVI1 complex locus
VGNC:43114
488148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MDS1 and EVI1 complex locus
Macaque
MDS1 and EVI1 complex locus
Mouse
Rat
Dog
MDS1 and EVI1 complex locus
Publication Statistics
PubMed Score 247.27
PubMed score by year
PubTator Score 281.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title