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Tbio
MLLT1
Protein ENL

Protein Summary
Description
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252674
  • ENSP00000252674
  • ENSG00000130382

Symbol
  • ENL
  • LTG19
  • YEATS1
  • ENL
  • LTG19
  • YEATS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
disease perturbation
0.74
tissue sample
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.66   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.66   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
29.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MLLT1, super elongation complex subunit
VGNC:13227
740990
Macaque
MLLT1, super elongation complex subunit
702105
Mouse
MGI:1927238
64144
Rat
RGD:1588581
301119
Dog
MLLT1, super elongation complex subunit
VGNC:43260
485023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MLLT1, super elongation complex subunit
Macaque
MLLT1, super elongation complex subunit
Mouse
Rat
Dog
MLLT1, super elongation complex subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03111-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Formation of RNA Pol II elongation complex (R-HSA-112382)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Protein-Protein Interactions (214)
1 – 10 of 214
ELL3
Tbio
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999999931
p_ni: 6.9e-8
p_wrong: 1e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999999092
p_ni: 9.08e-7
Score: 0.164
Data Source: BioPlex,STRINGDB
EPB41L2
Tbio
Novelty: 0.0311733
p_int: 0.999998265
p_ni: 0.000001368
p_wrong: 3.67e-7
Data Source: BioPlex
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.999992404
p_ni: 0.000007581
p_wrong: 1.4e-8
Score: 0.968
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999976102
p_ni: 0.000023869
p_wrong: 2.8e-8
Data Source: BioPlex
BPIFB1
Tbio
Novelty: 0.03980683
p_int: 0.999959718
p_ni: 0.000040277
p_wrong: 5e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
p_int: 0.999878031
p_ni: 0.000121939
p_wrong: 3e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.999498086
p_ni: 0.000495635
p_wrong: 0.00000628
Data Source: BioPlex
YAF2
Tbio
Novelty: 0.10772286
p_int: 0.999060613
p_ni: 0.000716405
p_wrong: 0.000222982
Data Source: BioPlex
PLEKHJ1
Tdark
Novelty: 1.44399298
p_int: 0.998914354
p_ni: 0.000942254
p_wrong: 0.000143391
Data Source: BioPlex
Publication Statistics
PubMed Score  296.66

PubMed score by year
PubTator Score  146.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer