Protein Summary
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
- ENST00000252674
- ENSP00000252674
- ENSG00000130382
- ENL
- LTG19
- YEATS1
- ENL
- LTG19
- YEATS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 0.87 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor binding site profile | 0.82 | ||
disease perturbation | 0.74 | ||
tissue sample | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.89 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.89 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (13)
Protein-Protein Interactions (214)
ELL3
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999999931
p_ni: 6.9e-8
p_wrong: 1e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.999999092
p_ni: 9.08e-7
Score: 0.164
Data Source: BioPlex,STRINGDB
EPB41L2
Novelty: 0.0311733
p_int: 0.999998265
p_ni: 0.000001368
p_wrong: 3.67e-7
Data Source: BioPlex
EAF1
Novelty: 0.81120425
p_int: 0.999992404
p_ni: 0.000007581
p_wrong: 1.4e-8
Score: 0.968
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999976102
p_ni: 0.000023869
p_wrong: 2.8e-8
Data Source: BioPlex
BPIFB1
Novelty: 0.03980683
p_int: 0.999959718
p_ni: 0.000040277
p_wrong: 5e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
CDK9
Family: Kinase
Novelty: 0.00210218
p_int: 0.999878031
p_ni: 0.000121939
p_wrong: 3e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
EPB41L1
Novelty: 0.02937451
p_int: 0.999498086
p_ni: 0.000495635
p_wrong: 0.00000628
Data Source: BioPlex
YAF2
Novelty: 0.10772286
p_int: 0.999060613
p_ni: 0.000716405
p_wrong: 0.000222982
Data Source: BioPlex
PLEKHJ1
Novelty: 1.44399298
p_int: 0.998914354
p_ni: 0.000942254
p_wrong: 0.000143391
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Formation of RNA Pol II elongation complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | RNA Polymerase II Pre-transcription Events | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RNA Polymerase II Transcription Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Formation of RNA Pol II elongation complex | ||||
Gene expression (Transcription) | ||||
RNA Polymerase II Pre-transcription Events | ||||
RNA Polymerase II Transcription | ||||
RNA Polymerase II Transcription Elongation | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | MLLT1, super elongation complex subunit | VGNC:13227 | 740990 | |||||
Macaque | MLLT1, super elongation complex subunit | 702105 | ||||||
Mouse | MGI:1927238 | 64144 | ||||||
Rat | RGD:1588581 | 301119 | ||||||
Dog | MLLT1, super elongation complex subunit | VGNC:43260 | 485023 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | MLLT1, super elongation complex subunit | |||||
Macaque | MLLT1, super elongation complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | MLLT1, super elongation complex subunit | |||||
Publication Statistics
PubMed Score 307.89
PubMed score by year
PubTator Score 146.59
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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