Tchem MLLT1 Protein ENL

Protein Summary

Description

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Uniprot Accession IDs

• Q03111
• Q14768

Gene Name

• MLLT1

Ensembl ID

• ENST00000252674
• ENSP00000252674
• ENSG00000130382

Symbol

• ENL
• LTG19
• YEATS1
• ENL
• LTG19
• YEATS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.82
disease perturbation	0.74
tissue sample	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Enl

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Enl

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Enl

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.89   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.89   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (13)

Explore Active Ligands

1 – 10 of 13

CHEMBL4206834

MLLT1Tchem

pKi : 6.92

CHEMBL4204744

MLLT1Tchem

pKi : 7.2

CHEMBL4211204

MLLT1Tchem

pKi : 7

CHEMBL4209820

MLLT1Tchem

pKi : 6.82

CHEMBL4216416

MLLT1Tchem

pKi : 7.05

CHEMBL4211714

MLLT1Tchem

pKi : 7.25

CHEMBL4216933

MLLT1Tchem

pKi : 6.43

CHEMBL4211962

MLLT1Tchem

pKi : 6.38

CHEMBL4216170

MLLT1Tchem

pKi : 6.54

CHEMBL4209508

MLLT1Tchem

pKi : 6.29

Protein-Protein Interactions (214)

Explore Interacting Targets

1 – 10 of 214

• See Interactions on String-DB

ELL3

Tbio

Family:  Enzyme

Novelty:  0.18245631

p_int:  0.999999931

p_ni:  6.9e-8

p_wrong:  1e-9

Score:  0.857

Data Source:  BioPlex,STRINGDB

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

p_int:  0.999999092

p_ni:  9.08e-7

Score:  0.164

Data Source:  BioPlex,STRINGDB

EPB41L2

Tbio

Novelty:  0.0311733

p_int:  0.999998265

p_ni:  0.000001368

p_wrong:  3.67e-7

Data Source:  BioPlex

EAF1

Tbio

Novelty:  0.81120425

p_int:  0.999992404

p_ni:  0.000007581

p_wrong:  1.4e-8

Score:  0.968

Data Source:  BioPlex,STRINGDB

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999976102

p_ni:  0.000023869

p_wrong:  2.8e-8

Data Source:  BioPlex

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999959718

p_ni:  0.000040277

p_wrong:  5e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

CDK9

Tchem

Family:  Kinase

Novelty:  0.00210218

p_int:  0.999878031

p_ni:  0.000121939

p_wrong:  3e-8

Score:  0.988

Data Source:  BioPlex,STRINGDB

EPB41L1

Tbio

Novelty:  0.02937451

p_int:  0.999498086

p_ni:  0.000495635

p_wrong:  0.00000628

Data Source:  BioPlex

YAF2

Tbio

Novelty:  0.10772286

p_int:  0.999060613

p_ni:  0.000716405

p_wrong:  0.000222982

Data Source:  BioPlex

PLEKHJ1

Tdark

Novelty:  1.44399298

p_int:  0.998914354

p_ni:  0.000942254

p_wrong:  0.000143391

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

KEGG (1)

Formation of RNA Pol II elongation complex (R-HSA-112382)

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Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Name	Explore in Pharos	Explore in Source
Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Gene expression (Transcription)	1452 targets	R-HSA-74160
RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (2)

Components (5)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
DNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1	1	1		58.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1		58.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Chromosomal rearrangement
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MLLT1, super elongation complex subunit	VGNC:13227	740990
Macaque	MLLT1, super elongation complex subunit		702105
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	MGI:1927238	64144
Rat	MLLT1, super elongation complex subunit	RGD:1588581	301119
Dog	MLLT1, super elongation complex subunit	VGNC:43260	485023

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MLLT1, super elongation complex subunit
Macaque	MLLT1, super elongation complex subunit
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Rat	MLLT1, super elongation complex subunit
Dog	MLLT1, super elongation complex subunit

Publication Statistics

PubMed Score 307.89

PubMed score by year

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PubTator Score 146.59

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (15)

Items per page:

10

0 of 0

PMID	Year	Title