Tchem MLLT1 Protein ENL

Protein Summary

Description

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Uniprot Accession IDs

• Q03111
• Q14768

Gene Name

• MLLT1

Ensembl ID

• ENST00000252674
• ENSP00000252674
• ENSG00000130382

Symbol

• ENL
• LTG19
• YEATS1
• ENL
• LTG19
• YEATS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.82
disease perturbation	0.74
tissue sample	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Enl

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Enl

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Enl

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.3   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.3   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0