Tchem MLLT1 Protein ENL

Protein Summary

Description

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Uniprot Accession IDs

• Q03111
• Q14768

Gene Name

• MLLT1

Ensembl ID

• ENST00000252674
• ENSP00000252674
• ENSG00000130382

Symbol

• ENL
• LTG19
• YEATS1
• ENL
• LTG19
• YEATS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.82
disease perturbation	0.74
tissue sample	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.89   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.89   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Active Ligands (13)

Explore Active Ligands

1 – 10 of 13

CHEMBL4206834

MLLT1Tchem

pKi : 6.92

CHEMBL4204744

MLLT1Tchem

pKi : 7.2

CHEMBL4211204

MLLT1Tchem

pKi : 7

CHEMBL4209820

MLLT1Tchem

pKi : 6.82

CHEMBL4216416

MLLT1Tchem

pKi : 7.05

CHEMBL4211714

MLLT1Tchem

pKi : 7.25

CHEMBL4216933

MLLT1Tchem

pKi : 6.43

CHEMBL4211962

MLLT1Tchem

pKi : 6.38

CHEMBL4216170

MLLT1Tchem

pKi : 6.54

CHEMBL4209508

MLLT1Tchem

pKi : 6.29

Protein-Protein Interactions (214)

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1 – 10 of 214

• See Interactions on String-DB

ELL3

Tbio

Family:  Enzyme

Novelty:  0.18245631

p_int:  0.999999931

p_ni:  6.9e-8

p_wrong:  1e-9

Score:  0.857

Data Source:  BioPlex,STRINGDB

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

p_int:  0.999999092

p_ni:  9.08e-7

Score:  0.164

Data Source:  BioPlex,STRINGDB

EPB41L2

Tbio

Novelty:  0.0311733

p_int:  0.999998265

p_ni:  0.000001368

p_wrong:  3.67e-7

Data Source:  BioPlex

EAF1

Tbio

Novelty:  0.81120425

p_int:  0.999992404

p_ni:  0.000007581

p_wrong:  1.4e-8

Score:  0.968

Data Source:  BioPlex,STRINGDB

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999976102

p_ni:  0.000023869

p_wrong:  2.8e-8

Data Source:  BioPlex

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999959718

p_ni:  0.000040277

p_wrong:  5e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

CDK9

Tchem

Family:  Kinase

Novelty:  0.00210218

p_int:  0.999878031

p_ni:  0.000121939

p_wrong:  3e-8

Score:  0.988

Data Source:  BioPlex,STRINGDB

EPB41L1

Tbio

Novelty:  0.02937451

p_int:  0.999498086

p_ni:  0.000495635

p_wrong:  0.00000628

Data Source:  BioPlex

YAF2

Tbio

Novelty:  0.10772286

p_int:  0.999060613

p_ni:  0.000716405

p_wrong:  0.000222982

Data Source:  BioPlex

PLEKHJ1

Tdark

Novelty:  1.44399298

p_int:  0.998914354

p_ni:  0.000942254

p_wrong:  0.000143391

Data Source:  BioPlex

Pathways (6)

Reactome (5)

KEGG (1)

Formation of RNA Pol II elongation complex (R-HSA-112382)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Name	Explore in Pharos	Explore in Source
Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Gene expression (Transcription)	1452 targets	R-HSA-74160
RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Gene Ontology Terms (10)

Functions (2)

Components (5)

Processes (3)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
DNA binding	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1	1	1		58.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	1		58.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Chromosomal rearrangement
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MLLT1, super elongation complex subunit	VGNC:13227	740990
Macaque	MLLT1, super elongation complex subunit		702105
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	MGI:1927238	64144
Rat	MLLT1, super elongation complex subunit	RGD:1588581	301119
Dog	MLLT1, super elongation complex subunit	VGNC:43260	485023

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MLLT1, super elongation complex subunit
Macaque	MLLT1, super elongation complex subunit
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Rat	MLLT1, super elongation complex subunit
Dog	MLLT1, super elongation complex subunit

Publication Statistics

PubMed Score 307.89

PubMed score by year

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PubTator Score 146.59

PubTator score by year

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