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Tbio
POU3F1
POU domain, class 3, transcription factor 1

Protein Summary
Description
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373012
  • ENSP00000362103
  • ENSG00000185668

Symbol
  • OCT6
  • OTF6
  • OCT6
  • OTF6
  • SCIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor
0.72
PubMedID
0.7
tissue sample
0.68
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.813
Data Source:  STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
Score:  0.755
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.75
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.731
Data Source:  STRINGDB
NPAS3
Tbio
Family:  TF
Novelty:  0.02597048
Score:  0.697
Data Source:  STRINGDB
SOX12
Tbio
Family:  TF
Novelty:  0.04738831
Score:  0.685
Data Source:  STRINGDB
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
Score:  0.653
Data Source:  STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
Score:  0.633
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.63
Data Source:  STRINGDB
MPZ
Tbio
Novelty:  0.00223212
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
4
63.7
pulse pressure measurement
1
1
2
50.6
2
2
0
1.1
48.3
heel bone mineral density
3
1
3
43.8
balding measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
63.7
pulse pressure measurement
2
50.6
0
1.1
48.3
heel bone mineral density
3
43.8
balding measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 3 homeobox 1
VGNC:14270
469287
Mouse
MGI:101896
18991
Dog
POU class 3 homeobox 1
VGNC:44829
100855694
Cow
POU class 3 homeobox 1
VGNC:33176
617830
Pig
POU class 3 homeobox 1
397513
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 3 homeobox 1
Mouse
Dog
POU class 3 homeobox 1
Cow
POU class 3 homeobox 1
Pig
POU class 3 homeobox 1
Publication Statistics
PubMed Score 372.76
PubMed score by year
PubTator Score 156.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title