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Tbio
HHEX
Hematopoietically-expressed homeobox protein HHEX

Protein Summary
Description
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282728
  • ENSP00000282728
  • ENSG00000152804

Symbol
  • HEX
  • PRH
  • PRHX
  • HEX
  • PRH
  • HMPH
  • PRHX
  • HOX11L-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.98
phenotype
0.89
transcription factor binding site profile
0.85
PubMedID
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.92   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.92   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
4
3
1.1
99.8
birth weight
2
2
2
88
sum of eosinophil and basophil counts
1
1
1
35.5
mean platelet volume
1
1
1
25.2
eosinophil percentage of granulocytes
1
1
1
23.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
99.8
birth weight
2
88
sum of eosinophil and basophil counts
1
35.5
mean platelet volume
1
25.2
eosinophil percentage of granulocytes
1
23.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hematopoietically expressed homeobox
VGNC:4703
450612
Macaque
hematopoietically expressed homeobox
699012
Mouse
MGI:96086
15242
Rat
RGD:619932
79237
Dog
hematopoietically expressed homeobox
VGNC:41680
608175
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hematopoietically expressed homeobox
Macaque
hematopoietically expressed homeobox
Mouse
Rat
Dog
hematopoietically expressed homeobox
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q03014-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (36)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (117)
1 – 10 of 117
CDKAL1
Tbio
Family: Enzyme
Novelty: 0.01013607
Score: 0.836
Data Source: STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00153967
Score: 0.791
Data Source: STRINGDB
SLC30A8
Tbio
Family: Transporter
Novelty: 0.00384775
Score: 0.789
Data Source: STRINGDB
IGF2BP2
Tbio
Novelty: 0.0105554
Score: 0.789
Data Source: STRINGDB
GATA6
Tbio
Family: TF
Novelty: 0.00267511
Score: 0.757
Data Source: STRINGDB
HEXB
Tchem
Family: Enzyme
Novelty: 0.0085045
Score: 0.753
Data Source: STRINGDB
HEXA
Tchem
Family: Enzyme
Novelty: 0.01134783
Score: 0.752
Data Source: STRINGDB
GM2A
Tbio
Novelty: 0.00574276
Score: 0.751
Data Source: STRINGDB
THADA
Tbio
Novelty: 0.06983966
Score: 0.751
Data Source: STRINGDB
TCF7L2
Tbio
Family: TF
Novelty: 0.00178694
Score: 0.741
Data Source: STRINGDB
Publication Statistics
PubMed Score  229.92

PubMed score by year
PubTator Score  557.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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