Tbio HHEX Hematopoietically-expressed homeobox protein HHEX

Protein Summary

Description

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q03014
• B1AQ17
• Q96CE9
• Homeobox protein HEX

Gene Name

• HHEX

Ensembl ID

• ENST00000282728
• ENSP00000282728
• ENSG00000152804

Symbol

• HEX
• PRH
• PRHX
• HEX
• PRH
• HMPH
• PRHX
• HOX11L-PEN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.98
phenotype	0.89
transcription factor binding site profile	0.85
PubMedID	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.32   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 446   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.32   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0