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Tbio
GSTM4
Glutathione S-transferase Mu 4

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of cer ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326729
  • ENSP00000316471
  • ENSG00000168765
  • ENST00000369836
  • ENSP00000358851

Symbol
  • GTM4
  • GSTM4-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
protein domain
0.73
molecular function
0.67
virus perturbation
0.64
disease
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.38   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.38   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DHA-derived sulfido conjugates
Reactome
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Name
Explore in Pharos
Explore in Source
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of DHA-derived sulfido conjugates
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of specialized proresolving mediators (SPMs)
Protein-Protein Interactions (96)
1 – 10 of 96
GSTM2
Tchem
Family: Enzyme
Novelty: 0.00334543
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
GSTM5
Tbio
Family: Enzyme
Novelty: 0.03763535
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.959
Data Source: BioPlex,STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.905
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.884
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.866
Data Source: STRINGDB
GPX8
Tbio
Family: Enzyme
Novelty: 0.02304355
Score: 0.866
Data Source: STRINGDB
GPX1
Tbio
Family: Enzyme
Novelty: 0.000826
Score: 0.861
Data Source: STRINGDB
GSTT2B
Tbio
Family: Enzyme
Novelty: 0.02334158
Score: 0.856
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.852
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.38

PubMed score by year
PubTator Score  18.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer