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Tbio
DST
Dystonin

Protein Summary
Description
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244364
  • ENSP00000244364
  • ENSG00000151914
  • ENST00000370765
  • ENSP00000359801
  • ENST00000370788
  • ENSP00000359824
  • ENST00000439203
  • ENSP00000404924

Symbol
  • BP230
  • BP240
  • BPAG1
  • DMH
  • DT
  • KIAA0728
  • DT
  • BPA
  • DMH
  • BP240
  • BPAG1
  • EBSB2
  • HSAN6
  • MACF2
  • CATX15
  • CATX-15
  • D6S1101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.99
transcription factor perturbation
0.99
interacting protein
0.95
cellular component
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.63   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.63   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.999999999
p_ni:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999916453
p_ni:  0.000083545
p_wrong:  2e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.998879458
p_ni:  0.001120542
Score:  0.189
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.96306539
p_ni:  0.03645131
p_wrong:  0.0004833
Data Source:  BioPlex
COL17A1
Tbio
Novelty:  0.00141446
Score:  0.994
Data Source:  STRINGDB
ITGB4
Tbio
Novelty:  0.00386461
Score:  0.976
Data Source:  Reactome,STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.944
Data Source:  Reactome,STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.942
Data Source:  Reactome,STRINGDB
LAMA3
Tbio
Novelty:  0.00733792
Score:  0.936
Data Source:  Reactome,STRINGDB
PLEC
Tbio
Novelty:  0.00223244
Score:  0.933
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Cell junction organization
Cell-Cell communication
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
81.6
serum alanine aminotransferase measurement
1
1
1
65.6
aspartate aminotransferase measurement
1
1
1
63.4
mean corpuscular volume
1
1
1
61.4
red blood cell density measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
81.6
serum alanine aminotransferase measurement
1
65.6
aspartate aminotransferase measurement
1
63.4
mean corpuscular volume
1
61.4
red blood cell density measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104627
13518
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Publication Statistics
PubMed Score 409.63
PubMed score by year
PubTator Score 137.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title