Protein Summary
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundl ...more
- ENST00000244364
- ENSP00000244364
- ENSG00000151914
- ENST00000370765
- ENSP00000359801
- ENST00000370788
- ENSP00000359824
- ENST00000439203
- ENSP00000404924
- BP230
- BP240
- BPAG1
- DMH
- DT
- KIAA0728
- DT
- BPA
- DMH
- BP240
- BPAG1
- EBSB2
- HSAN6
- MACF2
- CATX15
- CATX-15
- D6S1101
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.99 | ||
interacting protein | 0.95 | ||
cellular component | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 409.63 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 409.63 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
MAPRE1
Novelty: 0.01267772
p_int: 0.999999999
p_ni: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
COPS7B
Novelty: 0.63421506
p_int: 0.999916453
p_ni: 0.000083545
p_wrong: 2e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
MAGEA1
Novelty: 0.00506874
p_int: 0.998879458
p_ni: 0.001120542
Score: 0.189
Data Source: BioPlex,STRINGDB
TXLNA
Novelty: 0.02549959
p_int: 0.96306539
p_ni: 0.03645131
p_wrong: 0.0004833
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (6)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (8)
Components (23)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 3 | 3 | 81.6 | |||||
serum alanine aminotransferase measurement | 1 | 1 | 1 | 65.6 | |||||
aspartate aminotransferase measurement | 1 | 1 | 1 | 63.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 81.6 | |||||
serum alanine aminotransferase measurement | 1 | 65.6 | |||||
aspartate aminotransferase measurement | 1 | 63.4 | |||||
mean corpuscular volume | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
Publication Statistics
PubMed Score 409.63
PubMed score by year
PubTator Score 137.75
PubTator score by year
Related Publications
Text Mined References (78)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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