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Tbio
CFHR3
Complement factor H-related protein 3

Protein Summary
Description
Might be involved in complement regulation. The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367425
  • ENSP00000356395
  • ENSG00000116785
  • ENST00000391985
  • ENSP00000375845

Symbol
  • CFHL3
  • FHR3
  • FHR3
  • HLF4
  • CFHL3
  • FHR-3
  • DOWN16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.98
tissue
0.47
biological term
0.46
phenotype
0.45
cell line
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.84   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.84   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
meningococcal infection
1
1
0
1.6
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
meningococcal infection
0
1.6
84.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q02985-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (37)
1 – 10 of 37
CFH
Tbio
Novelty: 0.00065547
p_int: 0.99551977
p_ni: 4.07e-7
p_wrong: 0.004479823
Score: 0.966
Data Source: BioPlex,STRINGDB
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.987423707
p_ni: 0.012576281
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
C3
Tbio
Novelty: 0.00019115
Score: 0.986
Data Source: STRINGDB
CFI
Tbio
Novelty: 0.00271423
Score: 0.969
Data Source: STRINGDB
CFB
Tchem
Novelty: 0.00102672
Score: 0.968
Data Source: STRINGDB
CYFIP1
Tbio
Novelty: 0.01758346
Score: 0.937
Data Source: STRINGDB
TUBGCP5
Tbio
Novelty: 0.04863776
Score: 0.937
Data Source: STRINGDB
NIPA2
Tbio
Novelty: 0.05451663
Score: 0.937
Data Source: STRINGDB
CFHR1
Tbio
Novelty: 0.00676665
Score: 0.912
Data Source: STRINGDB
MNS1
Tbio
Novelty: 0.0349986
Score: 0.887
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.84

PubMed score by year
PubTator Score  43.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer