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Tbio
AKAP12
A-kinase anchor protein 12

Protein Summary
Description
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253332
  • ENSP00000253332
  • ENSG00000131016
  • ENST00000354675
  • ENSP00000346702
  • ENST00000359755
  • ENSP00000352794
  • ENST00000402676
  • ENSP00000384537

Symbol
  • AKAP250
  • SSeCKS
  • AKAP250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
PubMedID
0.95
small molecule perturbation
0.94
gene perturbation
0.93
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.52   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.52   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
Score:  0.855
Data Source:  STRINGDB
AKAP6
Tbio
Family:  Enzyme
Novelty:  0.02961416
Score:  0.806
Data Source:  STRINGDB
NNMT
Tchem
Family:  Enzyme
Novelty:  0.00602892
Score:  0.76
Data Source:  STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
Score:  0.745
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.727
Data Source:  STRINGDB
AKAP5
Tbio
Family:  Enzyme
Novelty:  0.00351101
Score:  0.724
Data Source:  STRINGDB
FHL2
Tbio
Novelty:  0.00501273
Score:  0.717
Data Source:  STRINGDB
AKAP13
Tbio
Family:  Enzyme
Novelty:  0.00726267
Score:  0.677
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.676
Data Source:  STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
78.5
hair color
2
2
0
1.1
68.5
monocyte count
1
1
1
57.8
sex hormone-binding globulin measurement
2
1
2
55.2
neutrophil count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
78.5
hair color
0
1.1
68.5
monocyte count
1
57.8
sex hormone-binding globulin measurement
2
55.2
neutrophil count
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 12
VGNC:2663
463076
Macaque
A-kinase anchoring protein 12
641446
Mouse
MGI:1932576
83397
Rat
RGD:70988
83425
Dog
A-kinase anchoring protein 12
VGNC:37754
476246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-kinase anchoring protein 12
Macaque
A-kinase anchoring protein 12
Mouse
Rat
Dog
A-kinase anchoring protein 12
Publication Statistics
PubMed Score 173.52
PubMed score by year
PubTator Score 70.27
PubTator score by year
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Related Publications
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PMID
Year
Title