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Tbio
CYP4A11
Cytochrome P450 4A11

Protein Summary
Description
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310638
  • ENSP00000311095
  • ENSG00000187048

Symbol
  • CYP4A2
  • CP4Y
  • CYP4A2
  • CYP4AII
  • CYPIVA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cellular component
0.73
drug
0.68
pathway
0.68
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.17   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.17   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
86.7
blood metabolite measurement
1
1
1
79.6
serum metabolite measurement
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
86.7
blood metabolite measurement
1
79.6
serum metabolite measurement
1
63.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450 4A11-like
709461
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450 4A11-like
Pathways (68)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Fatty acid metabolism
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (116)
1 – 10 of 116
CYP4A22
Tbio
Novelty: 0.01160613
p_int: 1
Score: 0.939
Data Source: BioPlex,STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.947
Data Source: STRINGDB
CYP2C8
Tchem
Novelty: 0.00186373
Score: 0.944
Data Source: STRINGDB
CYP2E1
Tchem
Novelty: 0.00030504
Score: 0.944
Data Source: STRINGDB
CYP2A6
Tchem
Novelty: 0.00105285
Score: 0.944
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.943
Data Source: STRINGDB
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.943
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.942
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.942
Data Source: STRINGDB
CYP2J2
Tchem
Novelty: 0.00534181
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.17

PubMed score by year
PubTator Score  93.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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