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Tbio
RPL6
60S ribosomal protein L6

Protein Summary
Description
Component of the large ribosomal subunit. (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202773
  • ENSP00000202773
  • ENSG00000089009
  • ENST00000424576
  • ENSP00000403172

Symbol
  • TXREB1
  • L6
  • TXREB1
  • SHUJUN-2
  • TAXREB107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
small molecule perturbation
1
co-expressed gene
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
94.4
high density lipoprotein cholesterol measurement
5
4
4
1.3
92
serum non-albumin protein measurement
1
2
2
91.5
drinking behavior
1
1
0
3.3
88.2
reticulocyte count
4
2
4
87.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
94.4
high density lipoprotein cholesterol measurement
4
1.3
92
serum non-albumin protein measurement
2
91.5
drinking behavior
0
3.3
88.2
reticulocyte count
4
87.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L6 pseudogene
696151
Mouse
MGI:108057
19988
Rat
RGD:619826
117042
Rat
Horse
ribosomal protein L6
100051509
Species
Name
OMA
EggNOG
Inparanoid
Macaque
60S ribosomal protein L6 pseudogene
Mouse
Rat
Rat
Horse
ribosomal protein L6
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02878-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (502)
1 – 10 of 502
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.995093698
p_ni:  0.004906302
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.962660853
p_ni:  0.037339147
Score:  0.632
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.950282326
p_ni:  0.049717674
Score:  0.999
Data Source:  BioPlex,STRINGDB
PTCD1
Tdark
Novelty:  0.17182155
p_int:  0.946000252
p_ni:  0.053999748
Score:  0.246
Data Source:  BioPlex,STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.944487041
p_ni:  0.055512959
Score:  0.562
Data Source:  BioPlex,STRINGDB
RALY
Tbio
Novelty:  0.03883322
p_int:  0.937093901
p_ni:  0.062906099
Score:  0.248
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.928232911
p_ni:  0.071767089
Score:  0.319
Data Source:  BioPlex,STRINGDB
MRPS22
Tbio
Novelty:  0.06827343
p_int:  0.924647336
p_ni:  0.075352664
Score:  0.616
Data Source:  BioPlex,STRINGDB
YBX3
Tbio
Family:  TF
Novelty:  0.00519768
p_int:  0.922968449
p_ni:  0.077031551
Score:  0.545
Data Source:  BioPlex,STRINGDB
LARP1
Tbio
Novelty:  0.0298044
p_int:  0.915312118
p_ni:  0.084687882
Score:  0.279
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  61.13

PubMed score by year
PubTator Score  17.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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