Tbio RPL6 60S ribosomal protein L6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60S Ribosomal Protein L6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60S Ribosomal Protein L6

Protein Summary

Description

Component of the large ribosomal subunit. (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q02878
• Q2M3Q3
• Q8WW97

Gene Name

• RPL6

Ensembl ID

• ENST00000202773
• ENSP00000202773
• ENSG00000089009
• ENST00000424576
• ENSP00000403172

Symbol

• TXREB1
• L6
• TXREB1
• SHUJUN-2
• TAXREB107

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
small molecule perturbation	1
co-expressed gene	0.87

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.13   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.13   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (41)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 41

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	2	2		94.4
high density lipoprotein cholesterol measurement	EFO_0004612	5	4	4	1.3	92
serum non-albumin protein measurement	EFO_0004568	1	2	2		91.5
drinking behavior	EFO_0004315	1	1	0	3.3	88.2
reticulocyte count	EFO_0007986	4	2	4		87.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2		94.4
high density lipoprotein cholesterol measurement	EFO_0004612	4	1.3	92
serum non-albumin protein measurement	EFO_0004568	2		91.5
drinking behavior	EFO_0004315	0	3.3	88.2
reticulocyte count	EFO_0007986	4		87.9

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	60S ribosomal protein L6 pseudogene		696151
Mouse	ribosomal protein L6	MGI:108057	19988
Rat	ribosomal protein L6	RGD:619826	117042
Rat	-
Horse	ribosomal protein L6		100051509

Species	Name	OMA	EggNOG	Inparanoid
Macaque	60S ribosomal protein L6 pseudogene
Mouse	ribosomal protein L6
Rat	ribosomal protein L6
Rat	-
Horse	ribosomal protein L6

Protein Structure (6 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02878-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (35)

Reactome (32)

KEGG (1)

PathwayCommons (1)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Gene Ontology Terms (20)

Functions (4)

Components (9)

Processes (7)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (502)

Explore Interacting Targets

1 – 10 of 502

• See Interactions on String-DB

RPL26L1

Tdark

Novelty:  0.75408617

p_int:  0.995093698

p_ni:  0.004906302

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.962660853

p_ni:  0.037339147

Score:  0.632

Data Source:  BioPlex,STRINGDB

RPL37A

Tbio

Novelty:  0.03475061

p_int:  0.950282326

p_ni:  0.049717674

Score:  0.999

Data Source:  BioPlex,STRINGDB

PTCD1

Tdark

Novelty:  0.17182155

p_int:  0.946000252

p_ni:  0.053999748

Score:  0.246

Data Source:  BioPlex,STRINGDB

MRPS9

Tdark

Novelty:  0.22906484

p_int:  0.944487041

p_ni:  0.055512959

Score:  0.562

Data Source:  BioPlex,STRINGDB

RALY

Tbio

Novelty:  0.03883322

p_int:  0.937093901

p_ni:  0.062906099

Score:  0.248

Data Source:  BioPlex,STRINGDB

CNBP

Tbio

Novelty:  0.00404247

p_int:  0.928232911

p_ni:  0.071767089

Score:  0.319

Data Source:  BioPlex,STRINGDB

MRPS22

Tbio

Novelty:  0.06827343

p_int:  0.924647336

p_ni:  0.075352664

Score:  0.616

Data Source:  BioPlex,STRINGDB

YBX3

Tbio

Family:  TF

Novelty:  0.00519768

p_int:  0.922968449

p_ni:  0.077031551

Score:  0.545

Data Source:  BioPlex,STRINGDB

LARP1

Tbio

Novelty:  0.0298044

p_int:  0.915312118

p_ni:  0.084687882

Score:  0.279

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  61.13

PubMed score by year

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PubTator Score  17.36

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Endoplasmic reticulum
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement
Beta blocking agent use measurement
bilirubin measurement
blood protein measurement
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body weight
cleft lip