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Tbio
GUCY2D
Retinal guanylyl cyclase 1

Protein Summary
Description
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254854
  • ENSP00000254854
  • ENSG00000132518

Symbol
  • CORD6
  • GUC1A4
  • GUC2D
  • RETGC
  • RETGC1
  • LCA
  • CYGD
  • LCA1
  • RCD2
  • CACD1
  • CORD5
  • CORD6
  • GUC2D
  • ROSGC
  • retGC
  • GUC1A4
  • RETGC-1
  • ROS-GC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.98
cell type or tissue
0.92
biological process
0.73
biological term
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.25   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.25   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.999
Data Source:  STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.992
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.966
Data Source:  STRINGDB
NCALD
Tbio
Novelty:  0.03665351
Score:  0.936
Data Source:  STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.909
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.9
Data Source:  STRINGDB
CNGB3
Tchem
Family:  IC
Novelty:  0.01174942
Score:  0.9
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
AIPL1
Tbio
Novelty:  0.01436649
Score:  0.868
Data Source:  STRINGDB
PDE6C
Tclin
Family:  Enzyme
Novelty:  0.02239368
Score:  0.857
Data Source:  STRINGDB
Nearest Tclin Targets (14)
Explore Nearest Tclin Targets
1 – 5 of 14
PDE6H
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE5A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6G
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  3
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  3
Pathways (15)
G alpha (i) signalling events (R-HSA-418594)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
58.4
serum non-albumin protein measurement
1
2
2
52.7
refractive error measurement
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
58.4
serum non-albumin protein measurement
2
52.7
refractive error measurement
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2D, retinal
VGNC:9315
750641
Macaque
guanylate cyclase 2D, retinal
716734
Mouse
MGI:105123
14919
Rat
RGD:620438
79222
Dog
guanylate cyclase 2D, retinal
VGNC:41570
403863
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2D, retinal
Macaque
guanylate cyclase 2D, retinal
Mouse
Rat
Dog
guanylate cyclase 2D, retinal
Publication Statistics
PubMed Score 199.25
PubMed score by year
PubTator Score 176.76
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Text